Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Gastric glomus tumor with uncertain malignant potential: case report of a rare cause of upper gastrointestinal bleeding

R. Fejes, KS. Gyorgyev, C. Góg, L. Krenács, T. Zombori, ZE. Széll, Z. Balajthy, T. Pancsa, Z. Simonka

. 2024 ; 22 (1) : 299. [pub] 20241113

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu kazuistiky, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25003468

Grantová podpora
7143 University of Szeged Open Access Fund
7143 University of Szeged Open Access Fund
7143 University of Szeged Open Access Fund
7143 University of Szeged Open Access Fund
7143 University of Szeged Open Access Fund
7143 University of Szeged Open Access Fund
7143 University of Szeged Open Access Fund
7143 University of Szeged Open Access Fund
7143 University of Szeged Open Access Fund

BACKGROUND: Glomus tumors (GTs) are mesenchymal neoplasms that are typically benign. Gastric GTs are uncommon and occur mainly in the upper gastrointestinal tract. Malignant gastric GTs are extremely rare, constituting less than 1% of gastric tumors. Because their features are similar to those of other tumors found in the same gastrointestinal region, such as stromal tumors, leiomyomas, lymphomas, and lipomas, the diagnosis is challenging. CASE PRESENTATION: A 52-year-old male patient presented with fatigue and melena. The initial endoscopic examination did not locate any source of bleeding. Six months later, pan-gastroscopy, performed due to progressive microcytic anemia, revealed a 40 × 30 mm polypoid lesion with deep ulcerations; histopathological analysis confirmed that it was a gastric GT with expression of alpha-actin and cadherin 17 and a Ki-67 index of 20%. The patient delayed surgical therapy until his symptoms worsened. Laparoscopic sleeve resection revealed a 65 × 45 × 25 mm tumor, and secondary immunohistochemical analysis revealed extensive spread into the mucosa and subserosa. Focally, the tumor bulged into some large veins. Genetic examination with RNA isolation further supported the histopathological diagnosis of gastric GT with uncertain malignant potential. CONCLUSIONS: This case underscores the diagnostic challenges posed by gastric GTs because they are rare and their clinical features are similar to those of other gastric tumors. Thorough histopathological and molecular analysis is essential for an accurate diagnosis. Surgical intervention remains the primary therapeutic approach. This case also emphasizes the need for long-term follow-up due to the potential for recurrence and malignancy.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25003468
003      
CZ-PrNML
005      
20250206104350.0
007      
ta
008      
250121s2024 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s12957-024-03563-7 $2 doi
035    __
$a (PubMed)39533374
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Fejes, Roland $u Institute for Surgical Research, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary. fejes.roland@med.u-szeged.hu $u Department of Internal Medicine, Hódmezővásárhely-Makó Healthcare Center, Makó, Hungary. fejes.roland@med.u-szeged.hu
245    10
$a Gastric glomus tumor with uncertain malignant potential: case report of a rare cause of upper gastrointestinal bleeding / $c R. Fejes, KS. Gyorgyev, C. Góg, L. Krenács, T. Zombori, ZE. Széll, Z. Balajthy, T. Pancsa, Z. Simonka
520    9_
$a BACKGROUND: Glomus tumors (GTs) are mesenchymal neoplasms that are typically benign. Gastric GTs are uncommon and occur mainly in the upper gastrointestinal tract. Malignant gastric GTs are extremely rare, constituting less than 1% of gastric tumors. Because their features are similar to those of other tumors found in the same gastrointestinal region, such as stromal tumors, leiomyomas, lymphomas, and lipomas, the diagnosis is challenging. CASE PRESENTATION: A 52-year-old male patient presented with fatigue and melena. The initial endoscopic examination did not locate any source of bleeding. Six months later, pan-gastroscopy, performed due to progressive microcytic anemia, revealed a 40 × 30 mm polypoid lesion with deep ulcerations; histopathological analysis confirmed that it was a gastric GT with expression of alpha-actin and cadherin 17 and a Ki-67 index of 20%. The patient delayed surgical therapy until his symptoms worsened. Laparoscopic sleeve resection revealed a 65 × 45 × 25 mm tumor, and secondary immunohistochemical analysis revealed extensive spread into the mucosa and subserosa. Focally, the tumor bulged into some large veins. Genetic examination with RNA isolation further supported the histopathological diagnosis of gastric GT with uncertain malignant potential. CONCLUSIONS: This case underscores the diagnostic challenges posed by gastric GTs because they are rare and their clinical features are similar to those of other gastric tumors. Thorough histopathological and molecular analysis is essential for an accurate diagnosis. Surgical intervention remains the primary therapeutic approach. This case also emphasizes the need for long-term follow-up due to the potential for recurrence and malignancy.
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    12
$a nádory žaludku $x patologie $x komplikace $x chirurgie $7 D013274
650    12
$a glomangiom $x patologie $x chirurgie $x komplikace $x diagnóza $7 D005918
650    12
$a gastrointestinální krvácení $x etiologie $x chirurgie $x patologie $7 D006471
650    _2
$a prognóza $7 D011379
650    _2
$a gastroskopie $7 D005773
655    _2
$a kazuistiky $7 D002363
655    _2
$a časopisecké články $7 D016428
700    1_
$a Gyorgyev, Kitti Szonja $u Department of Internal Medicine, Hódmezővásárhely-Makó Healthcare Center, Makó, Hungary
700    1_
$a Góg, Csaba $u Department of Internal Medicine, Hódmezővásárhely-Makó Healthcare Center, Makó, Hungary
700    1_
$a Krenács, László $u Laboratory of Tumor Pathology and Molecular Diagnostics, Szeged, Hungary
700    1_
$a Zombori, Tamás $u Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary
700    1_
$a Széll, Zsófia Eszter $u Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary
700    1_
$a Balajthy, Zsófia $u Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary
700    1_
$a Pancsa, Tamás $u Bioptical Laboratory Ltd, Pilsen, Czech Republic
700    1_
$a Simonka, Zsolt $u Department of Surgery, Albert Szent-Györgyi Health Center, University of Szeged, Semmelweis Street 8, Szeged, H-6725, Hungary. simonka.zsolt@med.u-szeged.hu
773    0_
$w MED00008253 $t World journal of surgical oncology $x 1477-7819 $g Roč. 22, č. 1 (2024), s. 299
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39533374 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250121 $b ABA008
991    __
$a 20250206104346 $b ABA008
999    __
$a ok $b bmc $g 2263317 $s 1239475
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 22 $c 1 $d 299 $e 20241113 $i 1477-7819 $m World journal of surgical oncology $n World J Surg Oncol $x MED00008253
GRA    __
$a 7143 $p University of Szeged Open Access Fund
GRA    __
$a 7143 $p University of Szeged Open Access Fund
GRA    __
$a 7143 $p University of Szeged Open Access Fund
GRA    __
$a 7143 $p University of Szeged Open Access Fund
GRA    __
$a 7143 $p University of Szeged Open Access Fund
GRA    __
$a 7143 $p University of Szeged Open Access Fund
GRA    __
$a 7143 $p University of Szeged Open Access Fund
GRA    __
$a 7143 $p University of Szeged Open Access Fund
GRA    __
$a 7143 $p University of Szeged Open Access Fund
LZP    __
$a Pubmed-20250121

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace