-
Something wrong with this record ?
The effect of 12-week high-dose Colostrum Bovinum supplementation on immunological, hematological and biochemical markers in endurance athletes: a randomized crossover placebo-controlled study
K. Durkalec-Michalski, N. Główka, T. Podgórski, M. Woźniewicz, PM. Nowaczyk
Language English Country Switzerland
Document type Journal Article, Randomized Controlled Trial
NLK
Directory of Open Access Journals
from 2010
Free Medical Journals
from 2010
PubMed Central
from 2010
Europe PubMed Central
from 2010
Open Access Digital Library
from 2010-01-01
Open Access Digital Library
from 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
from 2010
- MeSH
- Biomarkers * MeSH
- Adult MeSH
- Double-Blind Method MeSH
- Physical Endurance immunology MeSH
- Immunoglobulins blood MeSH
- Cross-Over Studies * MeSH
- Colostrum * immunology MeSH
- Humans MeSH
- Young Adult MeSH
- Dietary Supplements * MeSH
- Saliva * immunology metabolism MeSH
- Athletes * MeSH
- Animals MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Randomized Controlled Trial MeSH
BACKGROUND: Bovine colostrum (COL) is assumed to be one of the strongest natural immune stimulants. Regular ingestion of COL may contribute to improved immune response in athletes exposed to high training loads. METHODS: Twenty-eight endurance-trained males aged 31.1 ± 10.2 years (body mass 81.9 ± 9.0 kg; height 1.82 ± 0.06 m) completed this randomized double-blind placebo(PLA)-controlled crossover study aimed at investigating the effect of 12-week COL supplementation (25gCOL·day-1) on resting (REST), exercise-induced (POST-EX), and short-term post-exercise recovery (REC; 1 h after test exercise) changes in selected saliva and blood immunoglobulins (Ig), white blood cell (WBC) count and differential; as well as blood hematological, nutritional status and muscle damage indices. The protocol assumed 4 study visits - before/after supplementation with COL (COLPRE and COLPOST ) and PLA (PLAPRE and PLAPOST ). During testing sessions, incremental rowing test to exhaustion and swimming-specific performance test were introduced as exercise stimuli. RESULTS: At COLPOST visit the secretory IgA (SIgA) concentration in saliva was significantly higher at POST-EX and REC compared to REST (p<0.05). COL supplementation had no effect on blood IgA, IgE, IgD, IgG, and IgM concentrations. Furthermore, after COL supplementation decrease of hematocrit at REC (p<0.05) was revealed. CONCLUSIONS: 12-week supplementation with 25 gCOL·day-1 in endurance-trained male athletes resulted in a favorable increase in post-exercise concentration of salivary SIgA. COL seems to be a potential stimulator of local immune defense after exercise-induced homeostasis disturbances. Nevertheless, the lack of effect on blood markers indicates the need for further research in the area of mechanisms underlying the effect of the supposed COL immunological capacity.
Department of Human Nutrition and Dietetics Poznań University of Life Sciences Poznań Poland
Department of Physiology and Biochemistry Poznan University of Physical Education Poznań Poland
Department of Sports Dietetics Poznan University of Physical Education Poznań Poland
Sport Sciences Biomedical Department Charles University Prague Czechia
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25003836
- 003
- CZ-PrNML
- 005
- 20250206104730.0
- 007
- ta
- 008
- 250121e20241021sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3389/fimmu.2024.1425785 $2 doi
- 035 __
- $a (PubMed)39497827
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Durkalec-Michalski, Krzysztof $u Department of Sports Dietetics, Poznan University of Physical Education, Poznań, Poland $u Sport Sciences-Biomedical Department, Charles University, Prague, Czechia
- 245 14
- $a The effect of 12-week high-dose Colostrum Bovinum supplementation on immunological, hematological and biochemical markers in endurance athletes: a randomized crossover placebo-controlled study / $c K. Durkalec-Michalski, N. Główka, T. Podgórski, M. Woźniewicz, PM. Nowaczyk
- 520 9_
- $a BACKGROUND: Bovine colostrum (COL) is assumed to be one of the strongest natural immune stimulants. Regular ingestion of COL may contribute to improved immune response in athletes exposed to high training loads. METHODS: Twenty-eight endurance-trained males aged 31.1 ± 10.2 years (body mass 81.9 ± 9.0 kg; height 1.82 ± 0.06 m) completed this randomized double-blind placebo(PLA)-controlled crossover study aimed at investigating the effect of 12-week COL supplementation (25gCOL·day-1) on resting (REST), exercise-induced (POST-EX), and short-term post-exercise recovery (REC; 1 h after test exercise) changes in selected saliva and blood immunoglobulins (Ig), white blood cell (WBC) count and differential; as well as blood hematological, nutritional status and muscle damage indices. The protocol assumed 4 study visits - before/after supplementation with COL (COLPRE and COLPOST ) and PLA (PLAPRE and PLAPOST ). During testing sessions, incremental rowing test to exhaustion and swimming-specific performance test were introduced as exercise stimuli. RESULTS: At COLPOST visit the secretory IgA (SIgA) concentration in saliva was significantly higher at POST-EX and REC compared to REST (p<0.05). COL supplementation had no effect on blood IgA, IgE, IgD, IgG, and IgM concentrations. Furthermore, after COL supplementation decrease of hematocrit at REC (p<0.05) was revealed. CONCLUSIONS: 12-week supplementation with 25 gCOL·day-1 in endurance-trained male athletes resulted in a favorable increase in post-exercise concentration of salivary SIgA. COL seems to be a potential stimulator of local immune defense after exercise-induced homeostasis disturbances. Nevertheless, the lack of effect on blood markers indicates the need for further research in the area of mechanisms underlying the effect of the supposed COL immunological capacity.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a kolostrum $x imunologie $7 D003126
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a dospělí $7 D000328
- 650 12
- $a klinické křížové studie $7 D018592
- 650 12
- $a potravní doplňky $7 D019587
- 650 12
- $a sportovci $7 D056352
- 650 12
- $a biologické markery $7 D015415
- 650 _2
- $a dvojitá slepá metoda $7 D004311
- 650 12
- $a sliny $x imunologie $x metabolismus $7 D012463
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a fyzická vytrvalost $x imunologie $7 D010807
- 650 _2
- $a mladý dospělý $7 D055815
- 650 _2
- $a imunoglobuliny $x krev $7 D007136
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a randomizované kontrolované studie $7 D016449
- 700 1_
- $a Główka, Natalia $u Department of Sports Dietetics, Poznan University of Physical Education, Poznań, Poland
- 700 1_
- $a Podgórski, Tomasz $u Department of Physiology and Biochemistry, Poznan University of Physical Education, Poznań, Poland
- 700 1_
- $a Woźniewicz, Małgorzata $u Department of Human Nutrition and Dietetics, Poznań University of Life Sciences, Poznań, Poland
- 700 1_
- $a Nowaczyk, Paulina M $u Department of Sports Dietetics, Poznan University of Physical Education, Poznań, Poland
- 773 0_
- $w MED00181405 $t Frontiers in immunology $x 1664-3224 $g Roč. 15 (20241021), s. 1425785
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/39497827 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20250121 $b ABA008
- 991 __
- $a 20250206104726 $b ABA008
- 999 __
- $a ok $b bmc $g 2263540 $s 1239843
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 15 $c - $d 1425785 $e 20241021 $i 1664-3224 $m Frontiers in immunology $n Front Immunol $x MED00181405
- LZP __
- $a Pubmed-20250121
