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Loneliness, cerebrovascular and Alzheimer's disease pathology, and cognition

P. Lao, CB. Young, C. Ezeh, B. Lacayo, D. Seblova, RM. Andrews, L. Gibbons, AZ. Kraal, I. Turney, KD. Deters, V. Dotson, JJ. Manly, LL. Barnes, LB. Zahodne

. 2024 ; 20 (10) : 7113-7123. [pub] 20240905

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25004015

Grantová podpora
P30AG010161 (ROS) Rush Alzheimer's Disease Center
R01 AG067497 NIA NIH HHS - United States
P50 AG05136 NIA NIH HHS - United States
RF1AG022018 (MARS) Rush Alzheimer's Disease Center
R00 AG065506 NIA NIH HHS - United States
P30 AG010161 NIA NIH HHS - United States
AARFD-21-849349 Alzheimer's Association - United States
R00AG065506 NIA NIH HHS - United States
R13 AG030995 NIA NIH HHS - United States
R25AG059557 Summer of Translational Aging Research for Undergraduates
R25 AG059557 NIA NIH HHS - United States
R01AG017917 (MAP) Rush Alzheimer's Disease Center
P30 AG072978 NIA NIH HHS - United States
R01 AG017917 NIA NIH HHS - United States
P50 AG005136 NIA NIH HHS - United States
P30AG066462 Columbia Alzheimer's Disease Research Center
P30 AG066462 NIA NIH HHS - United States
R01 AG065359 NIA NIH HHS - United States
R01AG067497 NIA NIH HHS - United States
RF1 AG022018 NIA NIH HHS - United States
P30AG072978 Boston University Alzheimer's Disease Research Center
R01AG065359 NIA NIH HHS - United States

INTRODUCTION: Loneliness has a rising public health impact, but research involving neuropathology and representative cohorts has been limited. METHODS: Inverse odds of selection weights were generalized from the autopsy sample of Rush Alzheimer's Disease Center cohorts (N = 680; 89 ± 9 years old; 25% dementia) to the US-representative Health and Retirement Study (N = 8469; 76 ± 7 years old; 5% dementia) to extend external validity. Regressions tested cross-sectional associations between loneliness and (1) Alzheimer's disease (AD) and cerebrovascular pathology; (2) five cognitive domains; and (3) relationships between pathology and cognition, adjusting for depression. RESULTS: In weighted models, greater loneliness was associated with microinfarcts, lower episodic and working memory in the absence of AD pathology, lower working memory in the absence of infarcts, a stronger association of infarcts with lower episodic memory, and a stronger association of microinfarcts with lower working and semantic memory. DISCUSSION: Loneliness may relate to AD through multiple pathways involving cerebrovascular pathology and cognitive reserve. HIGHLIGHTS: Loneliness was associated with worse cognition in five domains. Loneliness was associated with the presence of microinfarcts. Loneliness moderated cognition-neuropathology associations. Transportability methods can provide insight into selection bias.

Citace poskytuje Crossref.org

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