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Stereoanalysis of the Antiparasitic Natural Product Callunene and Its Synthetic Intermediates
J. Ferenczei, V. Blahout, H. Dvořáková, A. Brancale, P. Cuřínová, M. Labíková, M. Kohout, V. Setnička, P. Perlíková
Journal of natural products.
2025 ;
88 (3) :
723-731.
[pub] 20250302
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Perzistentní odkaz
https://www.medvik.cz/link/bmc25009418
- MeSH
- antiparazitární látky chemie farmakologie MeSH
- biologické přípravky * chemie MeSH
- med analýza MeSH
- molekulární struktura MeSH
- stereoizomerie MeSH
- včely MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
The recent popularity of indoor farming has brought about problems with parasites spreading among pollinator colonies. The natural product callunene (1) can be used in the prophylaxis of bumblebees against Crithidia infection. Here, we report the synthesis of callunene (1), its enantioseparation, and a method for analyzing its optical purity. The approach was applied to determine the configuration of callunene extracted from heather honey. The proposed method is also applicable to the analysis of mixtures of diastereomers obtained during callunene synthesis, which allows the stereospecificity of individual reaction steps to be determined.
Citace poskytuje Crossref.org
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- $a Ferenczei, Jiří $u Department of Organic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, Prague 6 16628, Czech Republic $u Laboratory of Nuclear Magnetic Resonance Spectroscopy, University of Chemistry and Technology Prague, Technická 5, Prague 6 16628, Czech Republic
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- $a The recent popularity of indoor farming has brought about problems with parasites spreading among pollinator colonies. The natural product callunene (1) can be used in the prophylaxis of bumblebees against Crithidia infection. Here, we report the synthesis of callunene (1), its enantioseparation, and a method for analyzing its optical purity. The approach was applied to determine the configuration of callunene extracted from heather honey. The proposed method is also applicable to the analysis of mixtures of diastereomers obtained during callunene synthesis, which allows the stereospecificity of individual reaction steps to be determined.
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