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BRAF V600E positive papillary thyroid carcinoma (TERT and TP53 mutation coexistence excluded): Correlation of clinicopathological features and the extent of surgical treatment and its complications
J. Hlozek, J. Rotnagl, R. Holy, T. Hlozkova, B. Pekova Bulanova, V. Kuklikova, B. Bendlova, J. Soukup, P. Hrabal, J. Astl
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
Grantová podpora
MO 1012
Ministry of Defense of the Czech Republic - Czech Republic
NU21-01-00448
Ministry of Health of the Czech Republic - Czech Republic
00023761
MH CZ-DRO - Czech Republic
NLK
Directory of Open Access Journals
od 2019
ROAD: Directory of Open Access Scholarly Resources
od 2002
PubMed
40033809
DOI
10.32725/jab.2024.025
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- krční disekce škodlivé účinky MeSH
- lidé středního věku MeSH
- lidé MeSH
- mutace * MeSH
- nádorový supresorový protein p53 * genetika MeSH
- nádory štítné žlázy * genetika chirurgie patologie MeSH
- papilární karcinom štítné žlázy * genetika chirurgie patologie MeSH
- pooperační komplikace epidemiologie etiologie MeSH
- protoonkogenní proteiny B-Raf * genetika MeSH
- retrospektivní studie MeSH
- senioři MeSH
- telomerasa * genetika MeSH
- tyreoidektomie * škodlivé účinky metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
INTRODUCTION: Papillary thyroid carcinoma (PTC) frequently harbors the BRAF V600E mutation. Recent research suggests that aggressive behavior in BRAF V600E+ PTC may be due to an undetected mutation in the TERT gene. This study aims to observe the clinicopathological features of BRAF V600+ PTC and correlate them with surgical treatment complications. METHODS: A retrospective analysis was conducted on the BRAF V600E+ PTC cohort from July 2019 to January 2023. The histopathological features and surgical treatment (total thyroidectomy - group A, total thyroidectomy + central block neck dissection - group B) complications were correlated. Patients with TERT and TP53 mutation were excluded. Next-generation sequencing and real-time PCR were used for genetic analysis. RESULTS: Out of 121 PTCs, 65 cases showed BRAF V600E mutation with the following features: intracapsular spread (13.8%), extracapsular spread (27.7%), extrathyroidal spread (15.4%), multifocality (26.2%), angioinvasion (12.3%), and local metastasis (27.7%). The incidence of surgical complications in group A/B was: reversible recurrent laryngeal nerve (RLN) paresis 3.7/7.1%, RLN paresis permanent 0/2.4%, paresthesia 6.8/23.8%, hypocalcemia 36.4/61.9% on day 1 and 27.3/33.3% on day 3, and bleeding 2.3/9.5%. There was no significant difference in clinicopathological features between the BRAF V600E+ and BRAF V600E- PTC groups. Group B had a significantly higher incidence of hypoacalcaemia on postoperative day 1 (p = 0.047). CONCLUSION: The BRAF V600E mutation will certainly remain important in the preoperative diagnosis of PTC. The more radical surgical procedures currently recommended may be abandoned in the future, particularly elective CLND, which has a higher risk of postoperative complications.
Charles University 3rd Faculty of Medicine Prague Czech Republic
Institute of Endocrinology Department of Molecular Endocrinology Prague Czech Republic
Military University Hospital Department of Pathology Prague Czech Republic
Citace poskytuje Crossref.org
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