-
Something wrong with this record ?
Preparing O/W/O Emulsion for Curcumin (Curcuma longa) Delivery and In Vitro Digestibility Assay
K. Opustilová, B. Lapčíková, D. Sumczynski, R. Adámek
Language English Country Switzerland
Document type Journal Article
Grant support
IGA/FT/2024/005
Tomas Bata University in Zlin, Czech Republic
NLK
Free Medical Journals
from 2000
Freely Accessible Science Journals
from 2000
PubMed Central
from 2007
Europe PubMed Central
from 2007
ProQuest Central
from 2000-03-01
Open Access Digital Library
from 2000-01-01
Open Access Digital Library
from 2007-01-01
Health & Medicine (ProQuest)
from 2000-03-01
ROAD: Directory of Open Access Scholarly Resources
from 2000
PubMed
40565103
DOI
10.3390/ijms26125639
Knihovny.cz E-resources
- MeSH
- Curcuma * chemistry MeSH
- Emulsions chemistry MeSH
- Curcumin * chemistry administration & dosage MeSH
- Drug Delivery Systems * MeSH
- Oils chemistry MeSH
- Rheology MeSH
- Digestion MeSH
- Particle Size MeSH
- Water chemistry MeSH
- Publication type
- Journal Article MeSH
In this study, simple oil-in-water emulsions (O/W) and multiple O/W/O emulsions were employed as carriers for a curcumin delivery system. The stability of emulsions was evaluated using DSC (differential scanning calorimetry), accompanied by particle size measurement by DLS (dynamic light scattering) and rheological analysis. The amount of freezable water (Wfs) in O/W emulsion was determined to be 80.4%, while that in O/W/O emulsion was 23.7%. Multiple emulsions had a more complex structure than simple emulsions, being characterized by higher stability with predominant loss modulus over storage modulus (G" > G'). The mean surface diameter for O/W emulsion was 198.7 ± 9.8 nm, being approximately two times lower than that for multiple emulsions. Curcumin in vitro digestibility was observed for both emulsions and, additionally, the digestibility of fresh and dried curcuma root powders was investigated. Multiple emulsions were found to be a superior matrix for curcumin delivery, with higher stability and emulsion digestibility of 50.6% for the stomach and small intestine. In vitro digestion of dried curcuma powders and curcuma root samples was monitored by HPLC (high-performance liquid chromatography). The DMD (dry matter digestibility) for dried curcuma powders ranged between 52.9% to 78.8%, and for fresh curcuma (KF) was 95.5%.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25015316
- 003
- CZ-PrNML
- 005
- 20250731090916.0
- 007
- ta
- 008
- 250708s2025 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3390/ijms26125639 $2 doi
- 035 __
- $a (PubMed)40565103
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Opustilová, Kristýna $u Department of Food Technology, Faculty of Technology, Tomas Bata University in Zlin, Nam. T. G. Masaryka 5555, 760 01 Zlin, Czech Republic $1 https://orcid.org/0000000204046810
- 245 10
- $a Preparing O/W/O Emulsion for Curcumin (Curcuma longa) Delivery and In Vitro Digestibility Assay / $c K. Opustilová, B. Lapčíková, D. Sumczynski, R. Adámek
- 520 9_
- $a In this study, simple oil-in-water emulsions (O/W) and multiple O/W/O emulsions were employed as carriers for a curcumin delivery system. The stability of emulsions was evaluated using DSC (differential scanning calorimetry), accompanied by particle size measurement by DLS (dynamic light scattering) and rheological analysis. The amount of freezable water (Wfs) in O/W emulsion was determined to be 80.4%, while that in O/W/O emulsion was 23.7%. Multiple emulsions had a more complex structure than simple emulsions, being characterized by higher stability with predominant loss modulus over storage modulus (G" > G'). The mean surface diameter for O/W emulsion was 198.7 ± 9.8 nm, being approximately two times lower than that for multiple emulsions. Curcumin in vitro digestibility was observed for both emulsions and, additionally, the digestibility of fresh and dried curcuma root powders was investigated. Multiple emulsions were found to be a superior matrix for curcumin delivery, with higher stability and emulsion digestibility of 50.6% for the stomach and small intestine. In vitro digestion of dried curcuma powders and curcuma root samples was monitored by HPLC (high-performance liquid chromatography). The DMD (dry matter digestibility) for dried curcuma powders ranged between 52.9% to 78.8%, and for fresh curcuma (KF) was 95.5%.
- 650 12
- $a kurkumin $x chemie $x aplikace a dávkování $7 D003474
- 650 _2
- $a emulze $x chemie $7 D004655
- 650 12
- $a Curcuma $x chemie $7 D030024
- 650 _2
- $a velikost částic $7 D010316
- 650 _2
- $a trávení $7 D004063
- 650 12
- $a lékové transportní systémy $7 D016503
- 650 _2
- $a voda $x chemie $7 D014867
- 650 _2
- $a reologie $7 D012212
- 650 _2
- $a oleje $x chemie $7 D009821
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Lapčíková, Barbora $u Department of Food Technology, Faculty of Technology, Tomas Bata University in Zlin, Nam. T. G. Masaryka 5555, 760 01 Zlin, Czech Republic $1 https://orcid.org/0000000247130502 $7 mzk2007386080
- 700 1_
- $a Sumczynski, Daniela $u Department of Food Technology, Faculty of Technology, Tomas Bata University in Zlin, Nam. T. G. Masaryka 5555, 760 01 Zlin, Czech Republic $1 https://orcid.org/0000000293781429 $7 mzk2005294886
- 700 1_
- $a Adámek, Richard $u Department of Food Technology, Faculty of Technology, Tomas Bata University in Zlin, Nam. T. G. Masaryka 5555, 760 01 Zlin, Czech Republic $1 https://orcid.org/0000000349746279
- 773 0_
- $w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 26, č. 12 (2025)
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/40565103 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20250708 $b ABA008
- 991 __
- $a 20250731090911 $b ABA008
- 999 __
- $a ok $b bmc $g 2366273 $s 1252441
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2025 $b 26 $c 12 $e 20250612 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
- GRA __
- $a IGA/FT/2024/005 $p Tomas Bata University in Zlin, Czech Republic
- LZP __
- $a Pubmed-20250708