Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Preparing O/W/O Emulsion for Curcumin (Curcuma longa) Delivery and In Vitro Digestibility Assay

K. Opustilová, B. Lapčíková, D. Sumczynski, R. Adámek

. 2025 ; 26 (12) : . [pub] 20250612

Language English Country Switzerland

Document type Journal Article

Grant support
IGA/FT/2024/005 Tomas Bata University in Zlin, Czech Republic

In this study, simple oil-in-water emulsions (O/W) and multiple O/W/O emulsions were employed as carriers for a curcumin delivery system. The stability of emulsions was evaluated using DSC (differential scanning calorimetry), accompanied by particle size measurement by DLS (dynamic light scattering) and rheological analysis. The amount of freezable water (Wfs) in O/W emulsion was determined to be 80.4%, while that in O/W/O emulsion was 23.7%. Multiple emulsions had a more complex structure than simple emulsions, being characterized by higher stability with predominant loss modulus over storage modulus (G" > G'). The mean surface diameter for O/W emulsion was 198.7 ± 9.8 nm, being approximately two times lower than that for multiple emulsions. Curcumin in vitro digestibility was observed for both emulsions and, additionally, the digestibility of fresh and dried curcuma root powders was investigated. Multiple emulsions were found to be a superior matrix for curcumin delivery, with higher stability and emulsion digestibility of 50.6% for the stomach and small intestine. In vitro digestion of dried curcuma powders and curcuma root samples was monitored by HPLC (high-performance liquid chromatography). The DMD (dry matter digestibility) for dried curcuma powders ranged between 52.9% to 78.8%, and for fresh curcuma (KF) was 95.5%.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25015316
003      
CZ-PrNML
005      
20250731090916.0
007      
ta
008      
250708s2025 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/ijms26125639 $2 doi
035    __
$a (PubMed)40565103
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Opustilová, Kristýna $u Department of Food Technology, Faculty of Technology, Tomas Bata University in Zlin, Nam. T. G. Masaryka 5555, 760 01 Zlin, Czech Republic $1 https://orcid.org/0000000204046810
245    10
$a Preparing O/W/O Emulsion for Curcumin (Curcuma longa) Delivery and In Vitro Digestibility Assay / $c K. Opustilová, B. Lapčíková, D. Sumczynski, R. Adámek
520    9_
$a In this study, simple oil-in-water emulsions (O/W) and multiple O/W/O emulsions were employed as carriers for a curcumin delivery system. The stability of emulsions was evaluated using DSC (differential scanning calorimetry), accompanied by particle size measurement by DLS (dynamic light scattering) and rheological analysis. The amount of freezable water (Wfs) in O/W emulsion was determined to be 80.4%, while that in O/W/O emulsion was 23.7%. Multiple emulsions had a more complex structure than simple emulsions, being characterized by higher stability with predominant loss modulus over storage modulus (G" > G'). The mean surface diameter for O/W emulsion was 198.7 ± 9.8 nm, being approximately two times lower than that for multiple emulsions. Curcumin in vitro digestibility was observed for both emulsions and, additionally, the digestibility of fresh and dried curcuma root powders was investigated. Multiple emulsions were found to be a superior matrix for curcumin delivery, with higher stability and emulsion digestibility of 50.6% for the stomach and small intestine. In vitro digestion of dried curcuma powders and curcuma root samples was monitored by HPLC (high-performance liquid chromatography). The DMD (dry matter digestibility) for dried curcuma powders ranged between 52.9% to 78.8%, and for fresh curcuma (KF) was 95.5%.
650    12
$a kurkumin $x chemie $x aplikace a dávkování $7 D003474
650    _2
$a emulze $x chemie $7 D004655
650    12
$a Curcuma $x chemie $7 D030024
650    _2
$a velikost částic $7 D010316
650    _2
$a trávení $7 D004063
650    12
$a lékové transportní systémy $7 D016503
650    _2
$a voda $x chemie $7 D014867
650    _2
$a reologie $7 D012212
650    _2
$a oleje $x chemie $7 D009821
655    _2
$a časopisecké články $7 D016428
700    1_
$a Lapčíková, Barbora $u Department of Food Technology, Faculty of Technology, Tomas Bata University in Zlin, Nam. T. G. Masaryka 5555, 760 01 Zlin, Czech Republic $1 https://orcid.org/0000000247130502 $7 mzk2007386080
700    1_
$a Sumczynski, Daniela $u Department of Food Technology, Faculty of Technology, Tomas Bata University in Zlin, Nam. T. G. Masaryka 5555, 760 01 Zlin, Czech Republic $1 https://orcid.org/0000000293781429 $7 mzk2005294886
700    1_
$a Adámek, Richard $u Department of Food Technology, Faculty of Technology, Tomas Bata University in Zlin, Nam. T. G. Masaryka 5555, 760 01 Zlin, Czech Republic $1 https://orcid.org/0000000349746279
773    0_
$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 26, č. 12 (2025)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/40565103 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250708 $b ABA008
991    __
$a 20250731090911 $b ABA008
999    __
$a ok $b bmc $g 2366273 $s 1252441
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2025 $b 26 $c 12 $e 20250612 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
GRA    __
$a IGA/FT/2024/005 $p Tomas Bata University in Zlin, Czech Republic
LZP    __
$a Pubmed-20250708

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...