-
Je něco špatně v tomto záznamu ?
Long-term frailty and physical performance transitions in older people with type-2 diabetes. The MIDFRAIL randomized clinical study
O. Laosa, E. Topinkova, I. Bourdel-Marchasson, B. Vellas, M. Izquierdo, G. Paolisso, T. Hardman, A. Zeyfang, L. Pedraza, JA. Carnicero, L. Rodriguez-Mañas, AJ. Sinclair, MIDFRAIL consortium
Jazyk angličtina
Typ dokumentu časopisecké články, randomizované kontrolované studie
- MeSH
- diabetes mellitus 2. typu * terapie komplikace patofyziologie MeSH
- geriatrické hodnocení MeSH
- křehkost * terapie MeSH
- křehký senior * MeSH
- lidé MeSH
- odporový trénink MeSH
- samostatný způsob života MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- tělesná a funkční výkonnost * MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
AIMS: Type 2 diabetes (T2D) is associated with frailty in older people. We aim to explore changes in frailty status after ≥18 months of intervention. METHODS: 298 community-dwelling older adults (>70 years) participating in MIDFRAIL followed-up for 18-24 months were randomly allocated by trial site (cluster) to intervention IG (16-weeks resistance exercise program, nutritional-educational sessions, optimization of diabetes care), or usual care group (UCG). Frailty status was assessed by the Fried Frailty Phenotype criteria at baseline and final visit. Functional status was assessed by the SPPB in every visit. We used multivariate linear and logistic regression for continuous and dichotomous outcomes. This study was registered at Clinicaltrials.gov (NCT01654341). RESULTS: Mean age was 77.7 (SD 5.54), 47% were male, 32.9% frail and 67.1% prefrail. The probability of improving the frailty status and decreasing the number of Fried's frailty criteria was higher in the IG than in the UCG (OR 2.6, 95%CI 1.3-5.4; p = 0.009 and OR 1.9; 95%CI 1.1-3.1; p = 0.02, respectively). IG participants more frequently improved ≥1 point in SPPB score (OR 1.85; 95%CI 1.09-3.12; p = 0.022). These benefits were mainly accounted for the prefrail participants. CONCLUSIONS: The MIDFRAIL intervention improved frailty status and physical function at long-term follow-up in older people with T2D.
1st Faculty of Medicine Charles University Prague Czech Republic
Centre Hospitalier Universitaire de Bordeaux Bordeaux France
Centre Hospitalier Universitaire de Toulouse Toulouse France
Department of Geriatrics University Hospital of Getafe Madrid Spain
Foundation for Biomedical Research University Hospital of Getafe Madrid Spain
IdiSNA Navarra Institute for Health Research Public University of Navarra Pamplona Spain
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25016273
- 003
- CZ-PrNML
- 005
- 20250731092757.0
- 007
- ta
- 008
- 250708s2025 x f 000 0| g||
- 009
- AR
- 024 7_
- $a 10.1016/j.jnha.2025.100512 $2 doi
- 035 __
- $a (PubMed)39954533
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a x
- 100 1_
- $a Laosa, Olga $u Foundation for Biomedical Research-University Hospital of Getafe, Madrid, Spain; Biomedical Research Center Network for Frailty and Healthy Ageing (CIBERFES), Institute of Health Carlos III, Madrid, Spain
- 245 10
- $a Long-term frailty and physical performance transitions in older people with type-2 diabetes. The MIDFRAIL randomized clinical study / $c O. Laosa, E. Topinkova, I. Bourdel-Marchasson, B. Vellas, M. Izquierdo, G. Paolisso, T. Hardman, A. Zeyfang, L. Pedraza, JA. Carnicero, L. Rodriguez-Mañas, AJ. Sinclair, MIDFRAIL consortium
- 520 9_
- $a AIMS: Type 2 diabetes (T2D) is associated with frailty in older people. We aim to explore changes in frailty status after ≥18 months of intervention. METHODS: 298 community-dwelling older adults (>70 years) participating in MIDFRAIL followed-up for 18-24 months were randomly allocated by trial site (cluster) to intervention IG (16-weeks resistance exercise program, nutritional-educational sessions, optimization of diabetes care), or usual care group (UCG). Frailty status was assessed by the Fried Frailty Phenotype criteria at baseline and final visit. Functional status was assessed by the SPPB in every visit. We used multivariate linear and logistic regression for continuous and dichotomous outcomes. This study was registered at Clinicaltrials.gov (NCT01654341). RESULTS: Mean age was 77.7 (SD 5.54), 47% were male, 32.9% frail and 67.1% prefrail. The probability of improving the frailty status and decreasing the number of Fried's frailty criteria was higher in the IG than in the UCG (OR 2.6, 95%CI 1.3-5.4; p = 0.009 and OR 1.9; 95%CI 1.1-3.1; p = 0.02, respectively). IG participants more frequently improved ≥1 point in SPPB score (OR 1.85; 95%CI 1.09-3.12; p = 0.022). These benefits were mainly accounted for the prefrail participants. CONCLUSIONS: The MIDFRAIL intervention improved frailty status and physical function at long-term follow-up in older people with T2D.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a diabetes mellitus 2. typu $x terapie $x komplikace $x patofyziologie $7 D003924
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 12
- $a křehkost $x terapie $7 D000073496
- 650 12
- $a křehký senior $7 D016330
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a geriatrické hodnocení $7 D015577
- 650 12
- $a tělesná a funkční výkonnost $7 D000076604
- 650 _2
- $a odporový trénink $7 D055070
- 650 _2
- $a samostatný způsob života $7 D057187
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a randomizované kontrolované studie $7 D016449
- 700 1_
- $a Topinkova, Eva $u First Faculty of Medicine, Charles University, Prague, Czech Republic
- 700 1_
- $a Bourdel-Marchasson, Isabelle $u Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France
- 700 1_
- $a Vellas, Bruno $u Centre Hospitalier Universitaire de Toulouse, Toulouse, France
- 700 1_
- $a Izquierdo, Mikel $u IdiSNA, Navarra Institute for Health Research, Public University of Navarra, Pamplona, Spain
- 700 1_
- $a Paolisso, Giusseppe $u University of Campania-Luigi Vanvitelli, Naples, Italy
- 700 1_
- $a Hardman, Timothy $u Niche Science and Technology Ltd, Richmond, United Kingdom
- 700 1_
- $a Zeyfang, Andrej $u Ulm University, Ulm, Germany
- 700 1_
- $a Pedraza, Laura $u Foundation for Biomedical Research-University Hospital of Getafe, Madrid, Spain
- 700 1_
- $a Carnicero, Jose A $u Foundation for Biomedical Research-University Hospital of Getafe, Madrid, Spain
- 700 1_
- $a Rodriguez-Mañas, Leocadio $u Biomedical Research Center Network for Frailty and Healthy Ageing (CIBERFES), Institute of Health Carlos III, Madrid, Spain; Department of Geriatrics, University Hospital of Getafe, Madrid, Spain. Electronic address: leocadio.rodriguez@salud.madrid.org
- 700 1_
- $a Sinclair, Alan J $u Foundation for Diabetes Research in Older People (fDROP), and Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College, London, United Kingdom
- 710 2_
- $a MIDFRAIL consortium
- 773 0_
- $w MED00005383 $t The Journal of nutrition, health & aging $x 1760-4788 $g Roč. 29, č. 4 (2025), s. 100512
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/39954533 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20250708 $b ABA008
- 991 __
- $a 20250731091647 $b ABA008
- 999 __
- $a ok $b bmc $g 2366846 $s 1253398
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2025 $b 29 $c 4 $d 100512 $e 20250214 $i 1760-4788 $m The Journal of nutrition, health & aging $n J Nutr Health Aging $x MED00005383
- LZP __
- $a Pubmed-20250708
