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Observer Variation in the Diagnosis of Testicular Sex Cord-Stromal Tumors by a Genitourinary Pathology Society and International Society of Urological Pathology Panel: Paving the Way for a New Classification
DM. Berney, M. Colecchia, E. Comperat, KM. Cornejo, AJ. Gill, S. Gupta, JC. Cheville, MT. Idrees, CS. Kao, F. Maclean, A. Matoso, K. Michalova, MR. Raspollini, MR. Múgica, SK. Tickoo, T. Tsuzuki, TM. Ulbright, SR. Williamson, S. Siegmund, LM....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
NLK
Free Medical Journals
od 2000 do Před 1 rokem
Open Access Digital Library
od 2000-01-01
- MeSH
- gonadální stromální nádory * klasifikace diagnóza patologie MeSH
- konsensus MeSH
- lidé MeSH
- nádorové biomarkery analýza MeSH
- odchylka pozorovatele MeSH
- společnosti lékařské MeSH
- testikulární nádory * klasifikace diagnóza patologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
The diagnosis of sex cord-stromal tumors is challenging. They show a wide spectrum of behaviors and associations with clinically important pathogenic germline variants. In view of recent advances in molecular subtyping and risk factors, we wished to investigate the differences in diagnosis for a range of these tumors using expert genitourinary pathologists with an interest in this area. Forty-four tumors were selected, and 18 pathologists (members of TEsticular Sex cord-Stromal Tumor group) were invited to view the cases online and give a diagnosis. Consensus was taken as 70% agreement. Consensus was achieved in 59% (26/44) cases. However, there were many areas of disagreement, which included variability in the diagnosis of Sertoli cell and Leydig cell tumors, particularly in malignant lesions, and difficulty in the assignation of fibrothecomas or myoid gonadal stromal tumors, as well as variability in the diagnosis of granulosa cell tumors and in the diagnosis of rarer pediatric tumors. Pathologists placed different weights on positivity with some markers, particularly beta-catenin, S100, and SMA. Some pathologists diagnosed novel diagnostic entities, such as inflammatory and nested testicular sex cord tumors, not currently in the World Health Organization classification. Recommendations to assist in the construction of a new classification to achieve more concordance and better treatment of these rare tumors are included.
Department of Histopathology and Molecular Diagnostics Careggi University Hospital Florence Italy
Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota
Department of Pathology and Laboratory Medicine Cleveland Clinic Cleveland Ohio
Department of Pathology Cleveland Clinic Cleveland Ohio
Department of Pathology Douglass Hanly Moir Pathology Sonic Healthcare Sydney Australia
Department of Pathology Medical University Vienna Vienna Austria
Department of Pathology Vita Salute San Raffaele University Milan Italy
Department of Surgical Pathology Aichi Medical University Nagakute Japan
Hospital Universitario La Paz Universidad Autonoma de Madrid Madrid Spain
Massachusetts General Hospital Harvard Medical School Boston Massachusetts
Sydney Medical School University of Sydney Sydney New South Wales Australia
Citace poskytuje Crossref.org
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