High sensitivity of PHHC rat to dietary cholesterol
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
1286094
Knihovny.cz E-zdroje
- MeSH
- časové faktory MeSH
- cholesterol dietní metabolismus MeSH
- cholesterol krev MeSH
- esterifikace MeSH
- játra anatomie a histologie metabolismus MeSH
- krysa rodu Rattus MeSH
- lecitincholesterolacyltransferasa krev MeSH
- potkani Wistar MeSH
- triglyceridy krev MeSH
- velikost orgánu MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- cholesterol dietní MeSH
- cholesterol MeSH
- lecitincholesterolacyltransferasa MeSH
- triglyceridy MeSH
The Prague Hereditary Hypercholesterolaemic (PHHC) rat is a strain of the Wistar rat very sensitive to dietary cholesterol. The dynamics of changes in serum and liver lipids and lecithin: cholesterol acyltransferase (LCAT) were studied immediately after the switch to a high cholesterol diet. Immediate cumulation of free and esterified cholesterol in the liver after the increase in alimentary cholesterol intake is supposed to be the regulating step leading to a subsequent increase in serum cholesterol concentration. Activity of LCAT was negatively correlated to the concentration of free cholesterol in the liver, very early after the cholesterol diet was introduced, a possibility of a down regulation of enzyme synthesis similarly to the regulation of synthesis of cholesterol in hepatocytes was observed.
Global DNA methylation in rats´ liver is not affected by hypercholesterolemic diet
