Composition of lipid A in the S and R forms of Shigella dysenteriae serovar 1
Jazyk angličtina Země Německo Médium print
Typ dokumentu časopisecké články, Research Support, U.S. Gov't, Non-P.H.S.
- MeSH
- glukosamin analýza MeSH
- LD50 MeSH
- Limulus test MeSH
- lipid A chemie toxicita MeSH
- mastné kyseliny analýza MeSH
- myši inbrední ICR MeSH
- myši MeSH
- sacharidy analýza MeSH
- sérotypizace MeSH
- Shigella dysenteriae chemie klasifikace MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Názvy látek
- glukosamin MeSH
- lipid A MeSH
- mastné kyseliny MeSH
- sacharidy MeSH
A chemical analysis was performed of lipid A, isolated by acid hydrolysis of the lipopolysaccharide from the S and R forms of Shigella dysenteriae serovar 1. Differences in the moiety of both lipids and sugars were compared. The lipid portion consisted of a homologous series of fatty acids ranging from C12:0 to C18:0 (predominant homologues, C12:0, C14:0 and C16:0) and the homologous series of 3-hydroxy acids ranging from C12:0 to C16:0 (predominant homologue, 3-OH-C14:0). The major sugar portion consisted of D-glucosamine. The toxicity of lipid A in mice (LD50) ranged between 300-400 micrograms/mouse, and values from the Limulus amebocyte lysate assay were recorded as titres of 10(-5) to 10(-6) mg/ml.
Citace poskytuje Crossref.org
