Ofloxacin induces cytoplasmic respiration-deficient mutants in yeast Saccharomyces cerevisiae
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
1319844
DOI
10.1007/bf00351653
Knihovny.cz E-zdroje
- MeSH
- buněčné dělení účinky léků MeSH
- cykloheximid farmakologie MeSH
- DNA-topoisomerasy I účinky léků MeSH
- ethidium farmakologie MeSH
- glukosa metabolismus MeSH
- glycerol metabolismus MeSH
- koncentrace vodíkových iontů MeSH
- mitochondriální DNA účinky léků MeSH
- mutace MeSH
- ofloxacin farmakologie MeSH
- Saccharomyces cerevisiae účinky léků enzymologie genetika metabolismus MeSH
- spotřeba kyslíku MeSH
- teplota MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- cykloheximid MeSH
- DNA-topoisomerasy I MeSH
- ethidium MeSH
- glukosa MeSH
- glycerol MeSH
- mitochondriální DNA MeSH
- ofloxacin MeSH
Ofloxacin, a new quinolone with potent antibacterial activity, was also found to be effective against yeast. At relatively high concentrations, and at mild alkaline pH, ofloxacin inhibited the growth of yeast cells in medium containing glucose, and prevented growth on glycerol, as carbon and energy source. The cells growing in the presence of ofloxacin exhibited abberrantly budded forms, lost their viability and many of them converted to cytoplasmic respiration-deficient mutants. Induction of mutants was also observed under non-growing conditions. The petite clones analysed exhibited suppressiveness and contained different fragments of the wild-type mitochondrial genome.
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