Dose-response aggregometry--contribution to the precise platelet function evaluation
Language English Country United States Media print
Document type Comparative Study, Journal Article
PubMed
1604436
DOI
10.1016/0049-3848(92)90220-5
PII: 0049-3848(92)90220-5
Knihovny.cz E-resources
- MeSH
- Platelet Aggregation physiology MeSH
- Species Specificity MeSH
- Rats, Inbred Strains MeSH
- Rabbits MeSH
- Rats MeSH
- Humans MeSH
- Dogs MeSH
- Reproducibility of Results MeSH
- Platelet Function Tests methods MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Rats MeSH
- Humans MeSH
- Male MeSH
- Dogs MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
A method for the determination of blood platelet aggregability as the function of ADP concentration is described. Individual platelet aggregability was characterised by means of parameters of the sigmoidal relationship between the dose of the aggregating reagent and the aggregation curve amplitude. The method was applied to establish ADP-induced aggregability of various mammalian species. The aggregation curves of rabbit and rat platelets reached significantly lower maximum amplitudes than those of human and dog platelets. The eman concentration of ADP was significantly higher in dog platelets and the slope of the dose-response curve was significantly steeper in rat platelets compared to the other species studied. Some of the causes of individual intra-species ADP-induced aggregation variability revealed by means of dose-response aggregometry are discussed.
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