Dipeptidyl peptidase IV, prolyl endopeptidase and cathepsin B activities in primary human lung tumors and lung parenchyma
Jazyk angličtina Země Německo Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
1674512
DOI
10.1007/bf01625433
Knihovny.cz E-zdroje
- MeSH
- adenokarcinom enzymologie MeSH
- dipeptidylpeptidasa 4 MeSH
- dipeptidylpeptidasy a tripeptidylpeptidasy metabolismus MeSH
- dospělí MeSH
- endopeptidasy metabolismus MeSH
- fluorometrie MeSH
- kathepsin B metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory plic enzymologie chirurgie MeSH
- plíce enzymologie MeSH
- prolyloligopeptidasy MeSH
- senioři MeSH
- serinové endopeptidasy * MeSH
- spinocelulární karcinom enzymologie MeSH
- staging nádorů MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- dipeptidylpeptidasa 4 MeSH
- dipeptidylpeptidasy a tripeptidylpeptidasy MeSH
- endopeptidasy MeSH
- kathepsin B MeSH
- PREPL protein, human MeSH Prohlížeč
- prolyloligopeptidasy MeSH
- serinové endopeptidasy * MeSH
The activities of dipeptidyl peptidase IV (DPP-IV), prolyl endopeptidase (PE) and cathepsin B (CB) were investigated in primary human lung tumours and matched lung parenchyma, using continuous-rate fluorometric assays of the enzymes. Squamous-cell lung carcinomas showed significantly higher specific activities of all three enzymes studied. In lung adenocarcinomas only activities of PE and CB were increased significantly. In a limited number of primary human lung tumours of other histological types the activities of DPP-IV, PE and CB were also elevated. Mixing the matched homogenates of lung tumours and lung parenchyma gave additive activities for each enzyme studied. A significant correlation between tumour/lung ratios of specific activities of DPP-IV and CB was observed.
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