Dipeptidyl peptidase IV, prolyl endopeptidase and cathepsin B activities in primary human lung tumors and lung parenchyma
Language English Country Germany Media print
Document type Comparative Study, Journal Article
PubMed
1674512
DOI
10.1007/bf01625433
Knihovny.cz E-resources
- MeSH
- Adenocarcinoma enzymology MeSH
- Dipeptidyl Peptidase 4 MeSH
- Dipeptidyl-Peptidases and Tripeptidyl-Peptidases metabolism MeSH
- Adult MeSH
- Endopeptidases metabolism MeSH
- Fluorometry MeSH
- Cathepsin B metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Lung Neoplasms enzymology surgery MeSH
- Lung enzymology MeSH
- Prolyl Oligopeptidases MeSH
- Aged MeSH
- Serine Endopeptidases * MeSH
- Carcinoma, Squamous Cell enzymology MeSH
- Neoplasm Staging MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Dipeptidyl Peptidase 4 MeSH
- Dipeptidyl-Peptidases and Tripeptidyl-Peptidases MeSH
- Endopeptidases MeSH
- Cathepsin B MeSH
- PREPL protein, human MeSH Browser
- Prolyl Oligopeptidases MeSH
- Serine Endopeptidases * MeSH
The activities of dipeptidyl peptidase IV (DPP-IV), prolyl endopeptidase (PE) and cathepsin B (CB) were investigated in primary human lung tumours and matched lung parenchyma, using continuous-rate fluorometric assays of the enzymes. Squamous-cell lung carcinomas showed significantly higher specific activities of all three enzymes studied. In lung adenocarcinomas only activities of PE and CB were increased significantly. In a limited number of primary human lung tumours of other histological types the activities of DPP-IV, PE and CB were also elevated. Mixing the matched homogenates of lung tumours and lung parenchyma gave additive activities for each enzyme studied. A significant correlation between tumour/lung ratios of specific activities of DPP-IV and CB was observed.
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