High level of quinolone resistance in Escherichia coli from healthy chicken broilers
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- antibakteriální látky farmakologie MeSH
- bakteriální chromozomy MeSH
- bakteriální léková rezistence * MeSH
- chinolony farmakologie MeSH
- DNA gyráza genetika MeSH
- DNA-topoisomerasa IV genetika MeSH
- Escherichia coli účinky léků izolace a purifikace MeSH
- kur domácí mikrobiologie MeSH
- mikrobiální testy citlivosti MeSH
- missense mutace MeSH
- molekulární sekvence - údaje MeSH
- plazmidy MeSH
- proteiny z Escherichia coli genetika MeSH
- sekvence aminokyselin MeSH
- substituce aminokyselin MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antibakteriální látky MeSH
- chinolony MeSH
- DNA gyráza MeSH
- DNA-topoisomerasa IV MeSH
- proteiny z Escherichia coli MeSH
The development of resistance to quinolones (nalidixic acid, ciprofloxacin and enrofloxacin) in 2006-2008 was evaluated in 317 strains of Escherichia coli isolated from healthy chicken broilers from various farms. The isolates (2006/2007/2008) showed a high resistance to nalidixic acid (87/85/67 %), ciprofloxacin (CIP) (49/54/29 %) and enrofloxacin (ENR) (52/42/22 %). Nalidixic acid-resistant isolates with low level of MIC for CIP and ENR represented a single mutation; intermediary MIC for CIP and ENR were related to two mutations and high level resistance MIC for CIP (> or =4 mg/L) and ENR (> or =16 mg/L) represented three mutations (two in gyrA and one in parC). There was a correlation between the phenotype reading of high-level resistance and mutations in gyrA (Ser83Leu, Asp87Tyr or Asp87Asn) and parC (Ser80Ile) gene. Plasmid-mediated quinolone-resistance qnrS gene was detected in one Escherichia coli strain with a high level of ciprofloxacin resistance. Our results demonstrate the increase in occurrence of multiresistant E. coli strains with a high level of chromosomal and plasmid resistance to fluoroquinolones.
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