Pharmacokinetics and brain entry of alaptide, a novel nootropic agent, in mice, rats and rabbits
Language English Country England, Great Britain Media print
Document type Comparative Study, Journal Article
- MeSH
- Models, Biological MeSH
- Chromatography, Thin Layer MeSH
- Chinchilla MeSH
- Peptides, Cyclic administration & dosage blood pharmacokinetics urine MeSH
- Rats, Inbred Strains MeSH
- Rabbits MeSH
- Rats MeSH
- Brain metabolism MeSH
- Mice MeSH
- Neuropeptides administration & dosage blood pharmacokinetics urine MeSH
- Psychotropic Drugs administration & dosage blood pharmacokinetics urine MeSH
- Serum Albumin, Bovine MeSH
- In Vitro Techniques MeSH
- Protein Binding MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Rats MeSH
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- cyclo(alanine-(1-amino-1-cyclopentane)carbonyl) MeSH Browser
- Peptides, Cyclic MeSH
- Neuropeptides MeSH
- Psychotropic Drugs MeSH
- Serum Albumin, Bovine MeSH
Pharmacokinetics of a novel nootropic agent, alaptide, have been examined in plasma and brain of mice, rats and rabbits following an intravenous dose (1 mg kg-1). First-order equilibration rate constants between plasma and brain (kBO) were calculated by a two-compartment model with a linked compartment (brain). Brain alaptide equilibrates rapidly with the central compartment in mice and rats due to the high kBO/beta ratio. In rabbits the equilibration is much slower (kBO/beta approximately 1). Partition coefficients between brain and plasma calculated from areas under the brain and plasma concentration-time curves, are 0.479, 0.549 and 0.864, in mice, rats and rabbits, respectively.
References provided by Crossref.org
In vitro permeation of micronized and nanonized alaptide from semisolid formulations
