We report results on the age-dependent effect of the B (MHC) genotype on resistance to the growth of a second RSV tumour in chickens from highly inbred lines genetically resistant or susceptible to progressive growth of primary RSV-induced tumours. Furthermore, the second inoculation of RSV caused either accelerated or retarded growth of the primary tumours induced by the same virus. These two types of response to a second challenge with RSV were controlled by alleles of the chicken major histocompatibility (B) complex. The retarded growth of the primary tumours was found to be thymus-dependent. Furthermore, a clear-cut trans-complementation effect of two B alleles on the response to RSV challenge was demonstrated.

Institute of Molecular Genetics Czechoslovak Academy of Sciences Praha

src-specific immunity in inbred chickens bearing v-src DNA- and RSV-induced tumors

Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens