Haemodynamics and the participation of pressor systems in young and adult rats with age-dependent DOCA-salt hypertension
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
2954174
Knihovny.cz E-zdroje
- MeSH
- chlorid sodný MeSH
- deoxykortikosteron MeSH
- hemodynamika MeSH
- hypertenze chemicky indukované patofyziologie MeSH
- inbrední kmeny potkanů MeSH
- kaptopril farmakologie MeSH
- krevní tlak MeSH
- krysa rodu Rattus MeSH
- prazosin farmakologie MeSH
- stárnutí fyziologie MeSH
- vazomotorický systém patofyziologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- chlorid sodný MeSH
- deoxykortikosteron MeSH
- kaptopril MeSH
- prazosin MeSH
Increased systemic resistance is the main haemodynamic abnormality in DOCA-salt hypertension which is more pronounced in young than in adult rats. A mild increase of cardiac output also contributes to higher blood pressure in young animals. Arterial compliance is decreased only in young hypertensive rats. The acute blockade of different pressor systems indicates that the role of back-up pressor systems (vasopressin and angiotensin II) is increased in adult DOCA-salt hypertensive animals while the increased activity of adrenergic system and digoxin-like factors contributes to the enhanced hypertensive response of young rats.
Altered Balance between Vasoconstrictor and Vasodilator Systems in Experimental Hypertension
Research on Experimental Hypertension in Prague (1966-2009)
