Haemodynamics and the participation of pressor systems in young and adult rats with age-dependent DOCA-salt hypertension
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
2954174
Knihovny.cz E-resources
- MeSH
- Sodium Chloride MeSH
- Desoxycorticosterone MeSH
- Hemodynamics MeSH
- Hypertension chemically induced physiopathology MeSH
- Rats, Inbred Strains MeSH
- Captopril pharmacology MeSH
- Blood Pressure MeSH
- Rats MeSH
- Prazosin pharmacology MeSH
- Aging physiology MeSH
- Vasomotor System physiopathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Sodium Chloride MeSH
- Desoxycorticosterone MeSH
- Captopril MeSH
- Prazosin MeSH
Increased systemic resistance is the main haemodynamic abnormality in DOCA-salt hypertension which is more pronounced in young than in adult rats. A mild increase of cardiac output also contributes to higher blood pressure in young animals. Arterial compliance is decreased only in young hypertensive rats. The acute blockade of different pressor systems indicates that the role of back-up pressor systems (vasopressin and angiotensin II) is increased in adult DOCA-salt hypertensive animals while the increased activity of adrenergic system and digoxin-like factors contributes to the enhanced hypertensive response of young rats.
Altered Balance between Vasoconstrictor and Vasodilator Systems in Experimental Hypertension
Research on Experimental Hypertension in Prague (1966-2009)
