Long-term effect on the immune status of defined diets during the early postnatal period in the rat
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
3158013
Knihovny.cz E-resources
- MeSH
- Cell Division drug effects MeSH
- Time Factors MeSH
- Dietary Fats pharmacology MeSH
- Rats, Inbred Strains MeSH
- Rats MeSH
- Fatty Acids pharmacology MeSH
- Fatty Acids, Unsaturated pharmacology MeSH
- Animals, Newborn immunology MeSH
- Sarcoma immunology pathology MeSH
- Neoplasm Transplantation MeSH
- Antibody Formation drug effects MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Dietary Fats MeSH
- Fatty Acids MeSH
- Fatty Acids, Unsaturated MeSH
Germ-free and conventional infant rats delivered by hysterectomy were reared artificially, using one of two diets--diet LNa (with a high saturated fatty acid content) and diet K 50 (with a high unsaturated fatty acid content). Animals reared for a short time (up to 5 days) after birth on the LNa diet had a low antibody (PFC = plaque-forming lymphocyte) response and low resistance to Yoshida's sarcoma. Rats reared on the K 50 diet had the same response as the suckled controls. The first 5 days after birth were found to be the decisive period for long-term consequences of nutrition.
