Chemoprevention of cancer: selenium
Language English Country Great Britain, England Media print
Document type Journal Article, Review
- MeSH
- Bacteria drug effects MeSH
- Diet MeSH
- Neoplasms, Experimental prevention & control MeSH
- Glutathione Peroxidase metabolism MeSH
- Humans MeSH
- Mutation MeSH
- Cell Transformation, Neoplastic drug effects MeSH
- Neoplasms prevention & control MeSH
- Selenium administration & dosage blood pharmacokinetics pharmacology therapeutic use MeSH
- Tissue Distribution MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Glutathione Peroxidase MeSH
- Selenium MeSH
1. Selenium intake (in the form of selenite, selenate, selenomethionine, etc.) protects the organism against the action of some kinds of carcinogens. 2. People and animals having less Se in their blood are at a higher risk of acquiring cancer than those whose blood contains more of this element. 3. This chemopreventive action is probably due to antioxidant properties of Se, its involvements in the enzyme glutathione peroxidase as well as in the inhibition of enzymes converting carcinogens to their ultimate forms in the cell. 4. An intake of 150-300 micrograms of Se daily is considered to be adequate to protect the human organism without exhibiting the toxic properties of this element.
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