Diphosphate concentration does not correlate with the level of inorganic diphosphatase in Escherichia coli
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
6148295
DOI
10.1007/bf02875958
Knihovny.cz E-zdroje
- MeSH
- anorganická pyrofosfatasa MeSH
- difosfáty metabolismus MeSH
- Escherichia coli účinky léků enzymologie genetika MeSH
- fluoruracil farmakologie MeSH
- genetická transkripce účinky léků MeSH
- kinetika MeSH
- kyselina nalidixová farmakologie MeSH
- mutace MeSH
- pyrofosfatasy genetika metabolismus MeSH
- replikace DNA účinky léků MeSH
- uracil analogy a deriváty farmakologie MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- anorganická pyrofosfatasa MeSH
- azauracil MeSH Prohlížeč
- difosfáty MeSH
- fluoruracil MeSH
- kyselina nalidixová MeSH
- pyrofosfatasy MeSH
- uracil MeSH
Partial inhibition of DNA synthesis stimulates the production of inorganic diphosphatase in Escherichia coli but the changes in diphosphate (PPi) level observed did not correlate with the enzyme activity. An accumulation of PPi was observed in the presence of inhibitors of RNA synthesis or nucleotide synthesis. In the former case the level of the enzyme did not change but in the latter case it increased. Thus the amount of inorganic diphosphatase alone does not determine the concentration of PPi in E. coli.
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