Influence of ethosuximide on metrazol-induced seizures during ontogenesis in rats
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
6666517
Knihovny.cz E-resources
- MeSH
- Ethosuximide pharmacology MeSH
- Rats, Inbred Strains MeSH
- Rats MeSH
- Pentylenetetrazole antagonists & inhibitors toxicity MeSH
- Aging MeSH
- Dose-Response Relationship, Drug MeSH
- Seizures chemically induced prevention & control MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Ethosuximide MeSH
- Pentylenetetrazole MeSH
Effects of metrazol (pentylenetetrazole and ethosuximide were studied in male albino rats aged 7, 12, 18 and 90 days. The 18-day-old rats exhibited the highest sensitivity to metrazol. CD50s in the remaining three age groups were nearly the same. Ethosuximide was reliably effective against metrazol only in adult rats; in young animals it did not significantly change CD50s. Metrazol induced in ethosuximide-pretreated young rats either modified (long-lasting minimal seizures in 18-day-old animals) or new seizure patterns (minimal seizures in 7- and 12-day-old rats).
Pentylenetetrazol-induced seizures in rats: an ontogenetic study
