Influence of ethosuximide on metrazol-induced seizures during ontogenesis in rats
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
6666517
Knihovny.cz E-zdroje
- MeSH
- ethosuximid farmakologie MeSH
- inbrední kmeny potkanů MeSH
- krysa rodu Rattus MeSH
- pentylentetrazol antagonisté a inhibitory toxicita MeSH
- stárnutí MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- záchvaty chemicky indukované prevence a kontrola MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- ethosuximid MeSH
- pentylentetrazol MeSH
Effects of metrazol (pentylenetetrazole and ethosuximide were studied in male albino rats aged 7, 12, 18 and 90 days. The 18-day-old rats exhibited the highest sensitivity to metrazol. CD50s in the remaining three age groups were nearly the same. Ethosuximide was reliably effective against metrazol only in adult rats; in young animals it did not significantly change CD50s. Metrazol induced in ethosuximide-pretreated young rats either modified (long-lasting minimal seizures in 18-day-old animals) or new seizure patterns (minimal seizures in 7- and 12-day-old rats).
Pentylenetetrazol-induced seizures in rats: an ontogenetic study
