Influence of chronic mercury poisoning upon the connective tissue in rats. I. Effect of mercuric chloride on glycosaminoglycan levels in tissues, serum and urine
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
7697025
Knihovny.cz E-zdroje
- MeSH
- chlorid rtuťnatý krev toxicita moč MeSH
- chronická nemoc MeSH
- glykosaminoglykany analýza metabolismus MeSH
- krysa rodu Rattus MeSH
- otrava rtutí metabolismus MeSH
- potkani Wistar MeSH
- tkáňová distribuce MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- chlorid rtuťnatý MeSH
- glykosaminoglykany MeSH
Rats were intoxicated with mercuric chloride (1mg/kg b.w.) daily, for 12 weeks. A decrease in total glycosaminoglycan content was shown in the skin, the lungs, the liver and the heart muscle. These changes were accompanied by a slight alteration of the glycosaminoglycan pattern, a decrease in hyaluronic acid in the skin, the lungs and the heart muscle and an enhancement of heparan sulphate level in the kidneys. In serum of mercury-intoxicated rats, an increase in total glycosaminoglycan levels was shown. This enhancement was caused by elevation of almost all fractions. Urine output of glycosaminoglycans was higher in mercury-treated animals as compared to the controls.
