Localization of Borrelia burgdorferi in murine Lyme borreliosis by electron microscopy
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
7872439
DOI
10.4269/ajtmh.1995.52.128
Knihovny.cz E-zdroje
- MeSH
- bazální membrána parazitologie MeSH
- Borrelia burgdorferi komplex izolace a purifikace ultrastruktura MeSH
- cévní endotel parazitologie MeSH
- elektronová mikroskopie MeSH
- ELISA MeSH
- koronární cévy parazitologie MeSH
- lymeská nemoc parazitologie MeSH
- močový měchýř parazitologie MeSH
- myokard patologie MeSH
- myši inbrední C57BL MeSH
- myši inbrední DBA MeSH
- myši MeSH
- protilátky bakteriální krev MeSH
- srdce parazitologie MeSH
- western blotting MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- protilátky bakteriální MeSH
Lyme borreliosis is a newly recognized systemic infection with protean clinical manifestations. Because the localization of the causative spirochete (Borrelia burgdorferi) in infected tissues is unknown, we used electron microscopy to find spirochetes in the hearts of chronically infected mice. There were three predominant locations for the spirochete in the hearts. In mice infected for one month or less, the spirochetes were mostly in or around blood vessels. They were either in the lumen or in the perivascular space. Mice infected for more than one month had B. burgdorferi in cardiac myocytes as well, often with clear spaces around them. The third area in which spirochetes were common was collagen fibers; the borreliae were wrapped around fibers with their long axis parallel to the fibers. The number of spirochetes was relatively low, but there was no appreciable decrease in numbers of spirochetes with increasing time postinfection. Inflammatory infiltrates were primarily in the endocardium and pericardium, but spirochetes were generally not in or near areas of inflammation. These data are consistent with previously published information that have identified the heart as a site of chronic infection and inflammation in the mouse. The studies extend our understanding of the behavior of the spirochete in vivo by identifying common locations of B. burgdorferi and by noting the disparity between infection and inflammation.
Citace poskytuje Crossref.org
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