Protein profiling of human atrial and ventricular musculature: the effect of normoxaemia and hypoxaemia in congenital heart diseases
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
8280721
Knihovny.cz E-zdroje
- MeSH
- dítě MeSH
- kojenec MeSH
- kyslík metabolismus MeSH
- lidé MeSH
- mladiství MeSH
- myokard metabolismus MeSH
- předškolní dítě MeSH
- srdeční komory metabolismus MeSH
- srdeční síně metabolismus MeSH
- svalové proteiny metabolismus MeSH
- vrozené srdeční vady metabolismus MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- předškolní dítě MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- kyslík MeSH
- svalové proteiny MeSH
Samples of myocardial tissue were obtained during surgical intervention from children operated for different types of congenital heart disease (tetralogy of Fallot, ventricular and atrial septal defect). Sarcoplasmic, contractile and collagenous proteins were isolated by stepwise extraction from the both right ventricular and atrial musculature. It has been found that: a) the concentration of contractile proteins is significantly higher in the ventricles, b) the concentration of collagenous proteins is significantly higher in the atrium, c) the concentration of sarcoplasmic proteins was not different, d) in children with chronic hypoxia the above atrio-ventricular differences persisted. Moreover, the proportion of the soluble collagenous fraction in the atria was significantly increased.
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