Proton in vivo spectroscopy of patients with hyperphenylalaninaemia
Language English Country Germany Media print
Document type Journal Article
PubMed
8327063
DOI
10.1055/s-2008-1071525
Knihovny.cz E-resources
- MeSH
- Biopterins deficiency MeSH
- Choline analysis MeSH
- Demyelinating Diseases complications physiopathology MeSH
- Child MeSH
- Adult MeSH
- Phenylalanine analysis MeSH
- Phenylketonurias complications physiopathology MeSH
- Creatine analysis MeSH
- Aspartic Acid analysis MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Brain Chemistry MeSH
- Brain physiopathology MeSH
- Brain Diseases diagnosis etiology physiopathology MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biopterins MeSH
- Choline MeSH
- Phenylalanine MeSH
- Creatine MeSH
- Aspartic Acid MeSH
Changes in MR images and 1H spectra of 20 patients with hyperphenylalaninaemia were compared with data of controls. Major changes in T2 MR images were found in the periventricular area (20/19). Some patients showed lesions in MR images of basal ganglia (20/7) and in the cerebellum (20/4). The results of proton MR spectroscopy show no significant difference for NAA/Cr ratios but significant ones between the ratios of NAA/Cho (p = 0.97) and Cho/Cr (p = 0.98) of controls and patients with hyperphenylalaninaemia.
References provided by Crossref.org
Decreasing choline signal--a marker of phenylketonuria?
