The frequency of elimination of plasmid pKM101 from Salmonella typhimurium TA92 exposed to the action of 1-alkyl-1-ethylpiperidinium bromides and N-alkyl-N-[5-(benzoyloxy)-3-oxapentyl]-N,N-dimethylammonium bromides was non-linear in the homologous series. Change in the length of the alkyl chain markedly affected the elimination properties of the piperidine derivatives but had no effect on the elimination of benzoyl derivatives. Piperidines exhibited a weaker elimination capacity than the benzoyl derivatives. The most potent eliminator was the octylbenzoyl derivative, which causes the elimination of the plasmid in 80-85% cells.

Institute of Molecular and Subcellular Biology Comenius University Bratislava

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Mol Gen Genet. 1982;186(1):153-5 PubMed

J Bacteriol. 1968 Mar;95(3):1078-89 PubMed

Antimicrob Agents Chemother. 1973 Apr;3(4):456-62 PubMed

Pharmazie. 1990 Sep;45(9):695-6 PubMed

Bacteriol Rev. 1969 Jun;33(2):210-63 PubMed

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Mol Gen Genet. 1980 Apr;178(1):233-5 PubMed

J Bacteriol. 1967 Sep;94(3):687-90 PubMed