Antibody-targeted polymer-bound drugs
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
8763151
DOI
10.1007/bf02814745
Knihovny.cz E-resources
- MeSH
- Acrylamides administration & dosage adverse effects chemistry pharmacokinetics MeSH
- Thy-1 Antigens immunology MeSH
- Chlorophyllides MeSH
- Cyclosporine administration & dosage adverse effects pharmacokinetics MeSH
- Daunorubicin therapeutic use MeSH
- Doxorubicin analogs & derivatives therapeutic use MeSH
- Immunoconjugates * administration & dosage adverse effects chemistry pharmacokinetics MeSH
- Immunosuppressive Agents administration & dosage adverse effects chemistry pharmacokinetics MeSH
- Clinical Trials as Topic MeSH
- Polymethacrylic Acids therapeutic use MeSH
- Humans MeSH
- Lysosomes metabolism MeSH
- Histocompatibility Antigens Class II immunology MeSH
- Antibodies, Monoclonal administration & dosage chemistry immunology pharmacokinetics MeSH
- Mice, Inbred BALB C MeSH
- Mice, Nude MeSH
- Mice MeSH
- Neoplasms drug therapy MeSH
- Immune System Diseases drug therapy MeSH
- Porphyrins administration & dosage adverse effects pharmacokinetics MeSH
- Antibiotics, Antineoplastic administration & dosage adverse effects pharmacokinetics MeSH
- Antineoplastic Agents administration & dosage adverse effects pharmacokinetics MeSH
- Radiation-Sensitizing Agents administration & dosage adverse effects chemistry pharmacokinetics MeSH
- T-Lymphocyte Subsets immunology MeSH
- Tissue Distribution MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Acrylamides MeSH
- Thy-1 Antigens MeSH
- Chlorophyllides MeSH
- Cyclosporine MeSH
- daunomycin-N-(2-hydroxypropyl)methacrylamide copolymer conjugate MeSH Browser
- Daunorubicin MeSH
- doxorubicin-N-(2-hydroxypropyl)methacrylamide copolymer conjugate MeSH Browser
- Doxorubicin MeSH
- Immunoconjugates * MeSH
- Immunosuppressive Agents MeSH
- Polymethacrylic Acids MeSH
- Histocompatibility Antigens Class II MeSH
- Antibodies, Monoclonal MeSH
- N-(2-hydroxypropyl)methacrylamide MeSH Browser
- phytochlorin MeSH Browser
- Porphyrins MeSH
- Antibiotics, Antineoplastic MeSH
- Antineoplastic Agents MeSH
- Radiation-Sensitizing Agents MeSH
Drug targeting is an attractive new approach to killing cancer cells while leaving normal tissue unharmed. Recently we have developed a new generation of antibody-targeted immunosuppressive (cyclosporin A) and cytostatic (daunomycin, doxorubicin) drugs and photosensitizers (chlorin e6) effective in vitro and in vivo. The drugs and the targeting antibody (polyclonal and monoclonal) are conjugated to the oligopeptidic side chains of a water-soluble synthetic carrier, copolymer of N-(2-hydroxypropyl)methacrylamide. The composition of the side chains ensures the stability of the linkage between the drug and the polymeric carrier in the bloodstream and its intralysosomal degradability which is a prerequisite for the pharmacological activity of the preparation. Antibody-targeted polymer bound drugs show considerably decreased hepatotoxicity, cardiotoxicity, myelotoxicity and nephrotoxicity. Two adriamycin-HPMA copolymers are in Phase I/II clinical trials in United Kingdom.
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