A mathematical model and CD4+ lymphocyte dynamics in HIV infection
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
8969246
PubMed Central
PMC2639913
DOI
10.3201/eid0204.960405
Knihovny.cz E-zdroje
- MeSH
- aktivace lymfocytů MeSH
- aktivní imunita MeSH
- antigeny CD8 imunologie MeSH
- CD4-pozitivní T-lymfocyty imunologie MeSH
- CD8-pozitivní T-lymfocyty účinky léků imunologie MeSH
- HIV infekce farmakoterapie imunologie terapie MeSH
- imunoterapie MeSH
- lidé MeSH
- mezibuněčná komunikace MeSH
- pasivní imunizace MeSH
- počet CD4 lymfocytů MeSH
- teoretické modely * MeSH
- zidovudin terapeutické užití MeSH
- zpětná vazba MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antigeny CD8 MeSH
- zidovudin MeSH
The paper presents a model of CD4 + lymphocyte dynamics in HIV-infected persons. The model incorporates a feedback mechanism regulating the production of T lymphocytes and simulates the dynamics of CD8 + lymphocytes, whose production is assumed to be closely linked to that of CD4 + cells. Because CD4 + lymphocyte counts are a good prognostic indicator of HIV infection, the model was used to simulate such therapeutic interventions as chemotherapy and active and passive immunization. The model also simulated the therapeutic administration of anti-CD8 antibodies; this intervention was assumed to activate T-cell production by activating a feedback mechanism blocked by the high numbers of CD8 + lymphocytes present in HIV-infected persons. The character and implications of the model are discussed in the context of other mathematical models used in HIV infection.
Zobrazit více v PubMed
Immunobiology. 1991 Mar;182(2):178-87 PubMed
Folia Biol (Praha). 1991;37(1):42-51 PubMed
AIDS Res Hum Retroviruses. 1992 Jun;8(6):1039-50 PubMed
J Acquir Immune Defic Syndr. 1993 Feb;6(2):144-52 PubMed
J Acquir Immune Defic Syndr. 1993 Feb;6(2):153-61 PubMed
J Theor Biol. 1992 Dec 7;159(3):329-42 PubMed
Math Biosci. 1993 Mar;114(1):81-125 PubMed
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):544-8 PubMed
J Acquir Immune Defic Syndr. 1994 Mar;7(3):236-44 PubMed
Trends Microbiol. 1993 Apr;1(1):9-13 PubMed
Immunol Today. 1994 Jun;15(6):262-8 PubMed
J Theor Biol. 1994 Oct 21;170(4):367-91 PubMed
Folia Biol (Praha). 1994;40(3):103-11 PubMed
N Engl J Med. 1995 Jan 26;332(4):201-8 PubMed
N Engl J Med. 1995 Jan 26;332(4):209-16 PubMed
Nature. 1995 Jan 12;373(6510):117-22 PubMed
Nature. 1995 Jan 12;373(6510):123-6 PubMed
Science. 1995 Jan 27;267(5197):483-9 PubMed
Folia Biol (Praha). 1994;40(4):193-9 PubMed
Math Biosci. 1995 Feb;125(2):127-53 PubMed
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):496-505 PubMed
Int J Immunopharmacol. 1995 Jun;17(6):523-6 PubMed
Nature. 1995 Dec 7;378(6557):563 PubMed
Science. 1995 Dec 15;270(5243):1811-5 PubMed
Folia Biol (Praha). 1995;41(6):304-18 PubMed
J Math Biol. 1983;16(2):131-40 PubMed
Science. 1986 Dec 19;234(4783):1563-6 PubMed
Science. 1988 Feb 5;239(4840):617-22 PubMed
J Acquir Immune Defic Syndr. 1989;2(1):63-9 PubMed
Folia Biol (Praha). 1989;35(3):156-63 PubMed
Immunobiology. 1990 Aug;181(1):108-18 PubMed
J Infect Dis. 1992 Feb;165(2):352-63 PubMed
