Effect of stobadine on gastric mucosal injury after ischaemia/reperfusion
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
9085368
Knihovny.cz E-resources
- MeSH
- Ischemia complications pathology MeSH
- Capillary Permeability drug effects physiology MeSH
- Carbolines pharmacology MeSH
- Rats MeSH
- Rats, Wistar MeSH
- Anti-Ulcer Agents pharmacology MeSH
- Regional Blood Flow physiology MeSH
- Reperfusion Injury complications pathology MeSH
- Gastric Mucosa blood supply pathology MeSH
- Stomach Ulcer etiology pathology prevention & control MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- dicarbine MeSH Browser
- Carbolines MeSH
- Anti-Ulcer Agents MeSH
The ability of stobadine to prevent gastric mucosal injury was tested in rat gastric ischaemia induced by 30 min clamping of the coeliac artery with subsequent 30 min reperfusion. Serious injury of gastric mucosa (macroscopic and microscopic) and the increase of microvascular permeability was found after ischaemia/reperfusion in rats without stobadine. After oral pretreatment with stobadine (5 mg.kg-1, 30 min before surgery), the development of gastric mucosal lesions and changes of vascular permeability were significantly decreased.
