Chromosomal aberrations, sister-chromatid exchanges, cells with high frequency of SCE, micronuclei and comet assay parameters in 1, 3-butadiene-exposed workers
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
9804932
DOI
10.1016/s1383-5718(98)00135-1
PII: S1383-5718(98)00135-1
Knihovny.cz E-zdroje
- MeSH
- biologické markery MeSH
- butadieny škodlivé účinky MeSH
- chromozomální aberace * MeSH
- elektroforéza v agarovém gelu MeSH
- glutathiontransferasa chemie MeSH
- kouření MeSH
- látky znečišťující vzduch škodlivé účinky MeSH
- lidé MeSH
- lymfocyty ultrastruktura MeSH
- mikrojádra chromozomálně defektní MeSH
- mutageny MeSH
- polymorfismus genetický MeSH
- pracovní expozice MeSH
- výměna sesterských chromatid MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 1,3-butadiene MeSH Prohlížeč
- biologické markery MeSH
- butadieny MeSH
- glutathiontransferasa MeSH
- látky znečišťující vzduch MeSH
- mutageny MeSH
The association of occupational exposure to 1,3-butadiene (BD) and induction of cytogenetic damage in peripheral lymphocytes was studied in 19 male workers from a monomer production unit and 19 control subjects from a heat production unit. The exposure to BD was measured by passive personal monitors. The following biomarkers were used: chromosomal aberrations (CA), sister chromatid exchanges (SCE), cells with a high frequency of SCE (HFC), micronuclei, comet assay parameters like tail length (TL) and percentage of DNA in tail [T (%)] and polymorphisms of GSTM1 and GSTT1 genotypes. BD exposure with a median value of 0.53 mg/m3 (range: 0.024-23.0) significantly increased (a) the percentage of cells with chromosomal aberrations in exposed vs. control groups (3.11% vs. 2.03%, P<0.01), (b) the frequency of SCE per cell (6.96 vs. 4.87, P<0.001), and (c) the percentage of HFC (19.9% vs. 4.1%, P<0.001). BD exposure had no significant effects on formation of micronuclei and on comet assay parameters. Effect of smoking was observed only for HFC in BD-exposed group. GSTM1 genotype affected chromosomal aberrations in exposed group, while GSTT1 genotype affected chromosomal aberrations in controls. No effect of GSTM1 or GSTT1 genotypes was observed on any other biomarkers used.
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