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Záznam pochází z PubMed

Fetal growth and maternal exposure to particulate matter during pregnancy

Environmental health perspectives. 1999 Jun ; 107 (6) : 475-80.

Environ Health Perspect
ISSN 0091-6765
Zdroj

Jazyk angličtina Země Spojené státy americké Médium print

Typ dokumentu klinické zkoušky, časopisecké články, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S.

Perzistentní odkaz https://www.medvik.cz/link/pmid10339448

Online Plný text

PubMed 10339448
PubMed Central PMC1566587
DOI 10.1289/ehp.99107475
PII: sc271_5_1835
Knihovny.cz E-zdroje

MeSH
dospělí MeSH
embryonální a fetální vývoj účinky léků MeSH
látky znečišťující životní prostředí toxicita MeSH
lidé MeSH
matka - expozice noxám škodlivé účinky MeSH
odds ratio MeSH
růstová retardace plodu chemicky indukované patologie MeSH
těhotenství MeSH
znečištění tabákovým kouřem škodlivé účinky MeSH
Check Tag
dospělí MeSH
lidé MeSH
těhotenství MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
klinické zkoušky MeSH
práce podpořená grantem MeSH
Research Support, U.S. Gov't, Non-P.H.S. MeSH
Geografické názvy
Česká republika MeSH
Názvy látek
látky znečišťující životní prostředí MeSH
znečištění tabákovým kouřem MeSH

Prior studies reported an association between ambient air concentrations of total suspended particles and SO2 during pregnancy and adverse pregnancy outcomes. We examined the possible impact of particulate matter up to 10 microm (PM10) and up to 2.5 microm (PM2. 5) in size on intrauterine growth retardation (IUGR) risk in a highly polluted area of Northern Bohemia (Teplice District). The study group includes all singleton full-term births of European origin over a 2-year period in the Teplice District. Information on reproductive history, health, and lifestyle was obtained from maternal questionnaires. The mean concentrations of pollutants for each month of gestation were calculated using continuous monitoring data. Three intervals (low, medium, and high) were constructed for each pollutant (tertiles). Odds ratios (ORs) for IUGR for PM10 and PM2.5 levels were generated using logistic regression for each month of gestation after adjustment for potential confounding factors. Adjusted ORs for IUGR related to ambient PM10 levels in the first gestational month increased along the concentration intervals: medium 1.62 [95% confidence interval (CI), 1.07-2.46], high 2.64 (CI, 1.48-4.71). ORs for PM2.5 were 1.26 (CI, 0.81-1.95) and 2.11 (CI, 1. 20-3.70), respectively. No other associations of IUGR risk with particulate matter were found. Influence of particles or other associated air pollutants on fetal growth in early gestation is one of several possible explanations of these results. Timing of this effect is compatible with a current hypothesis of IUGR pathogenesis. Seasonal factors, one of the other possible explanations, is less probable. More investigation is required to examine these findings and alternative explanations.

Laboratory of Genetic Ecotoxicology Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine Prague Vídeñská Czech Republic

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