The relationship between intrauterine growth retardation (IUGR) and exposure to particulate matter [less than/equal to] 10 microm (PM(10)) and particulate matter [less than and equal to] 2.5 microm (PM(2.5))( )in early pregnancy was recently studied in the highly polluted district of Teplice (Northern Bohemia). From this observation rose the question about the possible role of the carcinogenic fraction of polycyclic aromatic hydrocarbons (c-PAHs), which are usually bound to fine particles. The impact of c-PAHs and fine particles on IUGR was analyzed in Teplice and in Prachatice, a region with similarly high c-PAH but low particle levels. All European, single live births occurring in a 4-year period in Teplice (n = 3,378) and Prachatice (n = 1,505) were included. Detailed personal data were obtained via questionnaires and medical records. Mean PM(10), PM(2.5,) and c-PAHs levels during the 9 gestational months (GM) were estimated for each mother. Adjusted odds ratios (AORs) of IUGR for three levels of c-PAHs (low, medium, and high) and for continuous data were estimated after adjustment for a range of covariates using logistic regression models. In the present 4-year sample from Teplice, previously published results about increasing IUGR risk after exposure to particles in the first GM were fully confirmed, but no such effects were found in Prachatice. The AOR of IUGR for fetuses from Teplice exposed to medium levels of c-PAHs in the first GM was 1.60 [confidence interval (CI), 1.06-2. 15], and to high levels 2.15 (CI, 27-3.63). An exposure-response relationship was established by analyzing the continuous data. For each 10 ng increase of c-PAHs in the first GM, the AOR was 1.22 (CI, 1.07-1.39). About the same relationship was observed in Prachatice in spite of the low particle levels. The results prove that exposure to c-PAHs in early gestation may influence fetal growth. The particulate matter-IUGR association observed earlier may be at least partly explained by the presence of c-PAHs on particle surfaces.

Laboratory of Genetic Ecotoxicology Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine Academy of Science of the Czech Republic Prague Czech Republic

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Am J Hypertens. 1991 Aug;4(8):700-8 PubMed

Toxicology. 1992;71(3):257-66 PubMed

Lancet. 1992 Oct 24;340(8826):1010-4 PubMed

N Engl J Med. 1993 Dec 9;329(24):1753-9 PubMed

Environ Health Perspect. 1993 Dec;101 Suppl 4:187-91 PubMed

Environ Health Perspect. 1995 Mar;103 Suppl 2:23-7 PubMed

Acta Obstet Gynecol Scand. 1995 Oct;74(9):693-7 PubMed

Environ Health Perspect. 1995 Jun;103(6):588-90 PubMed

Biochem Pharmacol. 1995 Oct 12;50(8):1171-80 PubMed

Arch Environ Health. 1995 Nov-Dec;50(6):407-15 PubMed

Hum Exp Toxicol. 1995 Jun;14(6):503-6 PubMed

Environ Health Perspect. 1997 May;105(5):514-20 PubMed

Environ Health Perspect. 1997 Jun;105(6):608-12 PubMed

Hum Exp Toxicol. 1997 Dec;16(12):716-21 PubMed

Am J Epidemiol. 1998 Feb 1;147(3):309-14 PubMed

J Expo Anal Environ Epidemiol. 1993;3 Suppl 1:187-99 PubMed

Mol Hum Reprod. 1999 Feb;5(2):125-31 PubMed

Mutat Res. 1999 Mar 15;440(1):45-58 PubMed

Environ Health Perspect. 1999 Jun;107(6):475-80 PubMed

Occup Environ Med. 1999 Aug;56(8):539-43 PubMed

Mutat Res. 1999 Jul 16;428(1-2):203-15 PubMed

Int J Environ Anal Chem. 1981;9(2):93-144 PubMed

Environ Health Perspect. 2000 Jul;108(7):647-54 PubMed

Experientia. 1964 Apr 15;20(4):224-6 PubMed

Teratology. 1979 Dec;20(3):365-76 PubMed

Biol Reprod. 1981 Feb;24(1):183-91 PubMed

Am J Obstet Gynecol. 1982 Aug 1;143(7):793-8 PubMed

Pediatr Res. 1984 Nov;18(11):1071-5 PubMed

Br J Obstet Gynaecol. 1986 Oct;93(10):1049-59 PubMed

Environ Res. 1989 Oct;50(1):173-83 PubMed

Carcinogenesis. 1990 Sep;11(9):1673-5 PubMed

J Clin Endocrinol Metab. 1991 Mar;72(3):718-23 PubMed

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