The influence of angiotensin II on sex-dependent proliferation of aortic VSMC isolated from SHR
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
10453758
Knihovny.cz E-resources
- MeSH
- Angiotensin II pharmacology MeSH
- Aorta cytology MeSH
- Cell Division drug effects MeSH
- Hypertension pathology physiopathology MeSH
- Blood Pressure physiology MeSH
- Rats MeSH
- Cells, Cultured MeSH
- Sex Characteristics MeSH
- Rats, Inbred SHR physiology MeSH
- Muscle, Smooth, Vascular cytology MeSH
- Systole MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Angiotensin II MeSH
The growth response to angiotensin II (Ang II) was studied using cultured vascular smooth muscle cells (VSMC) isolated from the aortae of male and female spontaneously hypertensive rats (SHR). Systolic and mean arterial blood pressure of 10-week-old males was significantly higher when compared to age-matched females. The specific growth rate of male VSMC was significantly higher on the third and sixth day after synchronisation. Angiotensin II in concentration 10(-7) M stimulated the specific growth rate only in male VSMC during the exponential phase of growth. Moreover, doubling time was 3 hours shorter in male VSMC in comparison with the females. Our results suggest that both the increased specific growth rate and augmented growth-response of male VSMC to Ang II may explain the higher sensitivity of males to hypertensive stimuli.
Research on Experimental Hypertension in Prague (1966-2009)
Hypertension after the Menopause: What Can We Learn from Experimental Studies?
