The influence of angiotensin II on sex-dependent proliferation of aortic VSMC isolated from SHR
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
10453758
Knihovny.cz E-zdroje
- MeSH
- angiotensin II farmakologie MeSH
- aorta cytologie MeSH
- buněčné dělení účinky léků MeSH
- hypertenze patologie patofyziologie MeSH
- krevní tlak fyziologie MeSH
- krysa rodu Rattus MeSH
- kultivované buňky MeSH
- pohlavní dimorfismus MeSH
- potkani inbrední SHR fyziologie MeSH
- svaly hladké cévní cytologie MeSH
- systola MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- angiotensin II MeSH
The growth response to angiotensin II (Ang II) was studied using cultured vascular smooth muscle cells (VSMC) isolated from the aortae of male and female spontaneously hypertensive rats (SHR). Systolic and mean arterial blood pressure of 10-week-old males was significantly higher when compared to age-matched females. The specific growth rate of male VSMC was significantly higher on the third and sixth day after synchronisation. Angiotensin II in concentration 10(-7) M stimulated the specific growth rate only in male VSMC during the exponential phase of growth. Moreover, doubling time was 3 hours shorter in male VSMC in comparison with the females. Our results suggest that both the increased specific growth rate and augmented growth-response of male VSMC to Ang II may explain the higher sensitivity of males to hypertensive stimuli.
Research on Experimental Hypertension in Prague (1966-2009)
Hypertension after the Menopause: What Can We Learn from Experimental Studies?
