Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1
Language English Country Greece Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
10639569
Knihovny.cz E-resources
- MeSH
- Antigens, Surface * drug effects MeSH
- Azoxymethane MeSH
- Escherichia coli MeSH
- Fluorouracil therapeutic use MeSH
- G(M2) Ganglioside therapeutic use MeSH
- Carcinogens MeSH
- Colorectal Neoplasms chemically induced drug therapy MeSH
- Rats MeSH
- NK Cell Lectin-Like Receptor Subfamily B MeSH
- Lectins, C-Type * MeSH
- Liposomes MeSH
- Drug Carriers MeSH
- Oligosaccharides therapeutic use MeSH
- Rats, Sprague-Dawley MeSH
- Antimetabolites, Antineoplastic therapeutic use MeSH
- Drug Screening Assays, Antitumor MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antigens, Surface * MeSH
- Azoxymethane MeSH
- Fluorouracil MeSH
- G(M2) Ganglioside MeSH
- Carcinogens MeSH
- NK Cell Lectin-Like Receptor Subfamily B MeSH
- Lectins, C-Type * MeSH
- Liposomes MeSH
- Drug Carriers MeSH
- Oligosaccharides MeSH
- Antimetabolites, Antineoplastic MeSH
Natural killer (NK) and T cells express a superfamily of proteins with structural features of C-type lectins. Recombinantly prepared soluble form of rat NKR-P1 (CD161) recognized carbohydrate GalNac and GlcNac moieties. Ganglioside GM2 and heparin related-IS oligosaccharides representing the high affinity ligands for this receptor, increased the sensitivity of targets for killing by the rat effectors isolated from blood and spleen in vitro. Based on these results, we investigated in vivo the possible therapeutic effect of GM2 and IS carried by liposomes during induced rat colorectal carcinogenesis. The reduction of cancer incidence versus the controls (50% vs 88.88%), approached the 5-fluorouracil treatment (41.66%).
