Fatty acid interaction with mitochondrial uncoupling proteins
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Adipose Tissue, Brown metabolism MeSH
- Ion Channels MeSH
- Humans MeSH
- Fatty Acids metabolism MeSH
- Membrane Proteins metabolism MeSH
- Mitochondrial Proteins MeSH
- Mitochondria metabolism MeSH
- Forecasting MeSH
- Proteolipids metabolism MeSH
- Plants MeSH
- Uncoupling Agents metabolism MeSH
- Carrier Proteins metabolism MeSH
- Uncoupling Protein 1 MeSH
- Binding Sites MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Ion Channels MeSH
- Fatty Acids MeSH
- Membrane Proteins MeSH
- Mitochondrial Proteins MeSH
- Proteolipids MeSH
- proteoliposomes MeSH Browser
- Uncoupling Agents MeSH
- Carrier Proteins MeSH
- UCP1 protein, human MeSH Browser
- Uncoupling Protein 1 MeSH
The phenomena of fatty acid interaction with mitochondrial integral membrane proteins, namely uncoupling proteins (UCPs), are reviewed to emphasize the fatty acid cycling mechanism that has been suggested to explain the UCP function. Fatty acid-induced uncoupling is suggested to serve in bioenergetic systems, to set the optimum efficiency, and to tune the degree of coupling of oxidative phosphorylation. Fatty acid interaction with the "classic" uncoupling protein (UCP1) from mitochondria of thermogenic brown adipose tissue (BAT) is well known. UCP1 is considered to mediate purine nucleotide-sensitive uniport of monovalent unipolar anions, including anionic fatty acids. The return of protonated fatty acid leads to H+ uniport and uncoupling. Experiments supporting this mechanism are also reviewed for plant uncoupling mitochondrial protein (PUMP) and ADP/ATP carrier. The fatty acid cycling mechanism is predicted, as well for the recently discovered uncoupling proteins, UCP2 and UCP3.
References provided by Crossref.org
Channel character of uncoupling protein-mediated transport
