Experimental Goettingen minipig and beagle dog as two species used in bioequivalence studies for clinical pharmacology (5-aminosalicylic acid and atenolol as model drugs)
Language English Country Slovakia Media print
Document type Journal Article
PubMed
10703724
Knihovny.cz E-resources
- MeSH
- Atenolol blood pharmacokinetics MeSH
- Biotransformation MeSH
- Humans MeSH
- Mesalamine blood pharmacokinetics MeSH
- Swine, Miniature MeSH
- Area Under Curve MeSH
- Swine MeSH
- Dogs MeSH
- Therapeutic Equivalency MeSH
- Chromatography, High Pressure Liquid MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Dogs MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Atenolol MeSH
- Mesalamine MeSH
Due to proven similarities in biotransformation between man and minipig, minipig seems to be the experimental animal of choice for preclinical pharmacokinetic studies when an experiment with a drug exhibiting a great first pass bioelimination (like 5-aminosalicylic acid) is to be realised. On the other hand, both minipig and dog may be suitable species for a pharmacokinetic study with a drug characterized by a small extent of first pass biotransformation (like atenolol).
