Experimental Goettingen minipig and beagle dog as two species used in bioequivalence studies for clinical pharmacology (5-aminosalicylic acid and atenolol as model drugs)
Jazyk angličtina Země Slovensko Médium print
Typ dokumentu časopisecké články
PubMed
10703724
Knihovny.cz E-zdroje
- MeSH
- atenolol krev farmakokinetika MeSH
- biotransformace MeSH
- lidé MeSH
- mesalamin krev farmakokinetika MeSH
- miniaturní prasata MeSH
- plocha pod křivkou MeSH
- prasata MeSH
- psi MeSH
- terapeutická ekvivalence MeSH
- vysokoúčinná kapalinová chromatografie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- psi MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- atenolol MeSH
- mesalamin MeSH
Due to proven similarities in biotransformation between man and minipig, minipig seems to be the experimental animal of choice for preclinical pharmacokinetic studies when an experiment with a drug exhibiting a great first pass bioelimination (like 5-aminosalicylic acid) is to be realised. On the other hand, both minipig and dog may be suitable species for a pharmacokinetic study with a drug characterized by a small extent of first pass biotransformation (like atenolol).
