Antipentylenetetrazol action of clobazam in developing rats
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
10783916
Knihovny.cz E-resources
- MeSH
- Anticonvulsants pharmacology MeSH
- Anti-Anxiety Agents pharmacology MeSH
- Benzodiazepines * MeSH
- Epilepsy, Generalized chemically induced drug therapy MeSH
- Clobazam MeSH
- Convulsants MeSH
- Rats MeSH
- Brain growth & development physiopathology MeSH
- Pentylenetetrazole MeSH
- Rats, Wistar MeSH
- Age Factors MeSH
- Dose-Response Relationship, Drug MeSH
- Seizures chemically induced drug therapy MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anticonvulsants MeSH
- Anti-Anxiety Agents MeSH
- Benzodiazepines * MeSH
- Clobazam MeSH
- Convulsants MeSH
- Pentylenetetrazole MeSH
Clobazam (0.5 to 7.5 mg/kg i.p.) was tested against motor seizures elicited by pentylenetetrazol in rats 7, 12, 18, 25 and 90 days old. Minimal, predominantly clonic seizures with preserved righting ability were reliably induced by pentylenetetrazol and suppressed by clobazam in rats aged 18 days or more. The incidence of minimal seizures after clobazam pretreatment was not increased in 7- and 12-day-old rat pups. Generalized tonic-clonic seizures were markedly suppressed by clobazam in all age groups. In 18-day-old and older animals clobazam doses suppressing generalized seizures were always lower than those necessary for exerting an effect on minimal seizures. The differences in clobazam action appearing at various levels of maturation are only quantitative.
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
