Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat
Language English Country Netherlands Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
Grant support
HL56028
NHLBI NIH HHS - United States
- MeSH
- Chromosomes genetics MeSH
- Genotype MeSH
- Hemodynamics MeSH
- Hypertension genetics pathology physiopathology MeSH
- Blood Pressure genetics MeSH
- Rats MeSH
- Quantitative Trait, Heritable * MeSH
- Chromosome Mapping MeSH
- Myocardium pathology MeSH
- Rats, Inbred BN MeSH
- Rats, Inbred SHR genetics MeSH
- Rats, Inbred WKY MeSH
- Animals, Congenic MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
- Comparative Study MeSH
OBJECTIVES: Total genome scans of genetically segregating populations derived from the spontaneously hypertensive rat (SHR) and other rat models of hypertension have suggested the presence of quantitative trait loci (QTL) regulating blood pressure and cardiac mass on multiple chromosomes, including chromosome 2. The objective of the current study was to directly test for the presence of a blood pressure QTL on rat chromosome 2. DESIGN: A new congenic strain was derived by replacing a segment of chromosome 2 in the SHR between D2Rat171 and D2Arb24 with the corresponding chromosome segment from the normotensive Brown Norway rat. Arterial pressures were directly monitored in conscious rats by radiotelemetry. RESULTS: We found that the SHR congenic strain (SHR-2) carrying a segment of chromosome 2 from the Brown Norway rat had significantly lower systolic and diastolic blood pressures than the SHR progenitor strain. The attenuation of hypertension in the SHR-2 congenic strain versus the SHR progenitor strain was accompanied by significant amelioration of cardiac hypertrophy. CONCLUSIONS: These findings demonstrate that gene(s) with major effects on blood pressure exist in the differential segment of chromosome 2 trapped within the new SHR.BN congenic strain.
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