Influence of the replacement of the oxo function with the thioxo group on the antimycobacterial activity of 3-aryl-6,8-dichloro-2H-1,3-benzoxazine-2,4(3H)-diones and 3-arylquinazoline-2,4(1H,3H)-diones
Language English Country France Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11718275
DOI
10.1016/s0014-827x(01)01134-x
PII: S0014-827X(01)01134-X
Knihovny.cz E-resources
- MeSH
- Antitubercular Agents chemical synthesis chemistry pharmacology MeSH
- Quinazolines chemical synthesis chemistry pharmacology MeSH
- Microbial Sensitivity Tests MeSH
- Mycobacterium drug effects MeSH
- Oxazines chemical synthesis chemistry pharmacology MeSH
- Structure-Activity Relationship MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antitubercular Agents MeSH
- Quinazolines MeSH
- Oxazines MeSH
Series of 3-phenyl-6,8-dichloro-2H-1,3-benzoxazine-2,4(3H)-dithiones, 3-arylquinazoline-2,4(1H,3H)-diones and 3-arylquinazoline-2,4(1H,3H)-dithiones were synthesized, and the antimycobacterial activities of the derivatives evaluated in vitro. The compounds were active against Mycobacterium tuberculosis and conditionally pathogenic mycobacteria (Mycobacterium kansasii and Mycobacterium avium). The replacement of oxygen by sulfur in 3-phenyl-6,8-dichloro-2H-1,3-benzoxazine-2.4(3H)-diones and 3-arylquinazoline-2,4(1H,3H)-diones gave rise to an increase of antimycobacterial activity. The most active compound was 3-(3-chlorophenyl)-6,8-dichloro-2H-1,3-benzoxazine-2,4(3H)-dithione.
References provided by Crossref.org
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