Functional magnetic resonance imaging during deep brain stimulation: a pilot study in four patients with Parkinson's disease
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11748747
DOI
10.1002/mds.1217
PII: 10.1002/mds.1217
Knihovny.cz E-resources
- MeSH
- Dominance, Cerebral MeSH
- Electric Stimulation Therapy * adverse effects MeSH
- Electrodes, Implanted MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging * MeSH
- Brain physiopathology MeSH
- Ventral Thalamic Nuclei physiopathology MeSH
- Subthalamic Nucleus physiopathology MeSH
- Parkinson Disease surgery therapy MeSH
- Pilot Projects MeSH
- Treatment Outcome MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Functional magnetic resonance imaging (fMRI) was performed in patients with Parkinson's disease during deep brain stimulation of the subthalamic nucleus (three patients) and during deep brain stimulation of the ventral intermedius nucleus of the thalamus (one patient). All showed an increase in blood oxygenation level-dependent signal in the subcortical regions ipsilateral to the stimulated nucleus. This effect cannot be simply explained by a mechanism of depolarization blockade; rather, it is caused by overstimulation of the target nucleus, resulting in the suppression of its spontaneous activity. We confirm that fMRI during deep brain stimulation is a safe method with considerable potential for elucidating the functional connectivity of the stimulated nuclei.
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