Ring substituted 3-phenyl-1-(2-pyrazinyl)-2-propen-1-ones as potential photosynthesis-inhibiting, antifungal and antimycobacterial agents
Language English Country France Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11902656
DOI
10.1016/s0014-827x(01)01187-9
PII: S0014-827X(01)01187-9
Knihovny.cz E-resources
- MeSH
- Antifungal Agents chemical synthesis pharmacology MeSH
- Antitubercular Agents chemical synthesis pharmacology MeSH
- Photosynthesis drug effects MeSH
- Herbicides chemical synthesis pharmacology MeSH
- Heterocyclic Compounds chemical synthesis pharmacology MeSH
- Fungi drug effects MeSH
- Magnetic Resonance Spectroscopy MeSH
- Microbial Sensitivity Tests MeSH
- Molecular Conformation MeSH
- Molecular Structure MeSH
- Mycobacterium tuberculosis drug effects MeSH
- Structure-Activity Relationship MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antifungal Agents MeSH
- Antitubercular Agents MeSH
- Herbicides MeSH
- Heterocyclic Compounds MeSH
Four series of ring substituted (E)-3-phenyl-1-(2-pyrazinyl)-2-propen-1-ones were prepared by means of modified Claisen-Schmidt condensation of acetylpyrazines with aromatic aldehydes. The structures were confirmed by elemental analysis, IR, 1H NMR and 13C NMR spectra. The compounds were tested for specific biological properties and some derivatives exhibited photosynthesis-inhibiting, antifungal and antimycobacterial properties. The most pronounced effects were observed with compounds substituted with phenolic groups. Ortho-hydroxyl substituted derivatives were more potent than the corresponding para-hydroxyl substituted analogues.
References provided by Crossref.org
Novel Halogenated Pyrazine-Based Chalcones as Potential Antimicrobial Drugs
