Antimykobakteriální úcinky pyrrolidinoethylesterů alkoxysubstituovaných fenylkarbamových kyselin
[Antimycobacterial effects of pyrrolidinoethylester alkoxysubstituted phenylcarbamic acids]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't
PubMed
12058355
- MeSH
- Antitubercular Agents chemistry pharmacology MeSH
- Carbamates chemistry pharmacology MeSH
- Microbial Sensitivity Tests MeSH
- Mycobacterium drug effects MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antitubercular Agents MeSH
- Carbamates MeSH
- phenylcarbamic acid MeSH Browser
Pyrrolidinoethylesters of alkoxysubstituted phenylcarbamic acids, formerly investigated for local anaesthetic activity, can be considered to be potential antituberculotics. They are effective in vitro against Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. Their effect increases with the length of the alkyl chain in the alkoxy group bound to the phenyl. The influence of the position of the alkoxyl chain on the phenyl is not too marked, but it seems to decrease in the series m-, p-, o-.
Antimycobacterial activity of piperidinylpropyl esters of alkoxy-substituted phenylcarbamic acids
Antimycobacterial activity of basic ethyl esters of alkoxy-substituted phenylcarbamic acids
