Effect of structure on antibiotic action of new 9-(ethylthio)acridines
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
12058388
DOI
10.1007/bf02817668
Knihovny.cz E-resources
- MeSH
- Acridines chemical synthesis chemistry pharmacology MeSH
- Anti-Bacterial Agents MeSH
- Anti-Infective Agents chemical synthesis chemistry pharmacology MeSH
- Bacteria drug effects MeSH
- Yeasts drug effects MeSH
- Microbial Sensitivity Tests MeSH
- Molecular Structure MeSH
- Structure-Activity Relationship MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acridines MeSH
- Anti-Bacterial Agents MeSH
- Anti-Infective Agents MeSH
Six new 9-(ethylthio)acridine derivatives were examined for antibacterial and antifungal activities with 10 bacterial and 8 yeast strains. The only active compounds were 2- and 3-amino derivatives. The observed MICs (mg/L) for 2-amino-9-(ethylthio)acridine (possessing the highest biological activity) were 12 (P. mirabilis), 30 (B. subtillis), 60 (C. freundii), 90 (E. coli), 128 (E. vulneris) and 500 (S. marcescens and S. aureus). Both amino derivatives have also lowest half-wave potential (E1/2) and field Swain-Lupton constants (describing oxidoreduction behavior) what supports the importance of acridine ion formation in the mechanism of antimicrobial action.
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