Spectrum of styrene-induced DNA adducts: the relationship to other biomarkers and prospects in human biomonitoring
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
12088719
DOI
10.1016/s1383-5742(02)00012-1
PII: S1383574202000121
Knihovny.cz E-resources
- MeSH
- DNA Adducts chemistry drug effects metabolism MeSH
- Biomarkers MeSH
- DNA metabolism MeSH
- Epoxy Compounds chemistry metabolism MeSH
- Risk Assessment MeSH
- Humans MeSH
- Environmental Monitoring MeSH
- Mutagens metabolism toxicity MeSH
- Occupational Exposure MeSH
- Styrene metabolism toxicity MeSH
- In Vitro Techniques MeSH
- Binding Sites MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- DNA Adducts MeSH
- Biomarkers MeSH
- DNA MeSH
- Epoxy Compounds MeSH
- Mutagens MeSH
- Styrene MeSH
- styrene oxide MeSH Browser
Styrene is an important industrial chemical that has shown genotoxicity in many toxicology assays. This is believed to be related to the DNA-binding properties of styrene-7,8-oxide (SO), a major metabolite of styrene. In this review, we have summarized knowledge on various aspects of styrene genotoxicity, especially in order to understand the formation and removal of primary DNA lesions, and the usefulness of biomarkers for risk assessment. Biological significances of specific DNA adducts and their role in the cascade of genotoxic events are discussed. Links between markers of external and internal exposure are evaluated, as well as metabolic aspects leading to the formation of DNA adducts and influencing biomarkers of biological effect. Finally, we suggest a design of a population study, which may contribute to our understanding genotoxic events in the exposure either to single xenobiotic or complex mixture.
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