Role of CD4+ and CD8+ T lymphocytes in the protection of mice against Encephalitozoon intestinalis infection
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- CD4-pozitivní T-lymfocyty imunologie transplantace MeSH
- CD8-pozitivní T-lymfocyty imunologie transplantace MeSH
- elektronová mikroskopie MeSH
- Encephalitozoon imunologie ultrastruktura MeSH
- encephalitozoonóza imunologie prevence a kontrola MeSH
- imunoterapie MeSH
- lymfocytární deplece MeSH
- modely nemocí na zvířatech MeSH
- myši SCID MeSH
- myši MeSH
- převzatá imunita MeSH
- transfuze lymfocytů * MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Severe combined immunodeficient (SCID) mice reconstituted with spleen cells from naive adult BALB/c mice were completely resistant to peroral infection with Encephalitozoon intestinalis (Calli, Kotler and Orenstein, 1993) Canning, Field, Hing and Marriott, 1994, whereas control, non-reconstituted SCID mice succumbed to the infection. The role of T-lymphocyte subpopulations in the protection against peroral E. intestinalis infection was studied in adoptive transfer experiments using SCID mice. SCID mice reconstituted with both CD4+ and CD8+ T-lymphocyte-depleted splenocytes succumbed to the peroral route of infection. In contrast, SCID mice reconstituted with either CD4+-depleted or CD8+ T-lymphocyte-depleted splenocytes completely resolved the infection. This indicates that CD4+ and CD8+ T-lymphocyte subpopulations play a substantive role in protection against peroral infection with the microsporidian, E. intestinalis.
Citace poskytuje Crossref.org
Chronic Infections in Mammals Due to Microsporidia
