Role of CD4+ and CD8+ T lymphocytes in the protection of mice against Encephalitozoon intestinalis infection
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- CD4-Positive T-Lymphocytes immunology transplantation MeSH
- CD8-Positive T-Lymphocytes immunology transplantation MeSH
- Microscopy, Electron MeSH
- Encephalitozoon immunology ultrastructure MeSH
- Encephalitozoonosis immunology prevention & control MeSH
- Immunotherapy MeSH
- Lymphocyte Depletion MeSH
- Disease Models, Animal MeSH
- Mice, SCID MeSH
- Mice MeSH
- Adoptive Transfer MeSH
- Lymphocyte Transfusion * MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Severe combined immunodeficient (SCID) mice reconstituted with spleen cells from naive adult BALB/c mice were completely resistant to peroral infection with Encephalitozoon intestinalis (Calli, Kotler and Orenstein, 1993) Canning, Field, Hing and Marriott, 1994, whereas control, non-reconstituted SCID mice succumbed to the infection. The role of T-lymphocyte subpopulations in the protection against peroral E. intestinalis infection was studied in adoptive transfer experiments using SCID mice. SCID mice reconstituted with both CD4+ and CD8+ T-lymphocyte-depleted splenocytes succumbed to the peroral route of infection. In contrast, SCID mice reconstituted with either CD4+-depleted or CD8+ T-lymphocyte-depleted splenocytes completely resolved the infection. This indicates that CD4+ and CD8+ T-lymphocyte subpopulations play a substantive role in protection against peroral infection with the microsporidian, E. intestinalis.
References provided by Crossref.org
Chronic Infections in Mammals Due to Microsporidia
